Immunohistochemical Study of Postnatal Neurogenesi

Authors: Judita Orendáčová Eniko Račeková Martin Orendáč Marcela Martončíková Kamila Saganová Kamila Lievajová Henrieta Abdiová Ján Labun Ján Gálik

Publish Date: 2009/03/21

Volume: 29, Issue: 6-7, Pages: 981-990

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Abstract

It is well established that strong electromagnetic fields EMFs can give rise to acute health effects such as burns which can be effectively prevented by respecting exposure guidelines and regulations Current concerns are instead directed toward the possibility that longterm exposure to weak EMF might have detrimental health effects due to some biological mechanism to date unknown 1 The possible risk due to pulsed EMF at frequency 245 GHz and mean power density 28 mW/cm2 on rat postnatal neurogenesis was studied in relation to the animal’s age duration of the exposure dose and postirradiation survival 2 Proliferating cells marker BrdU was used to map age and doserelated immunohistochemical changes within the rostral migratory stream RMS after wholebody exposure of newborn P7 and senescent 24 months rats 3 Two doserelated exposure patterns were performed to clarify the cumulative effect of EMF shortterm exposure dose 2 days irradiation 4 h/day versus longterm exposure dose 3 days irradiation 8 h/day both followed by acute 24 h and chronic 1–4 weeks postirradiation survival 4 We found that the EMF induces significant age and dosedependent changes in proliferating cell numbers within the RMS Our results indicate that the concerns about the possible risk of EMF generated in connection with production transmission distribution and the use of electrical equipment and communication sets are justified at least with regard to early postnatal neurogenesis

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