Authors: Hui Dong Yunfu Ma Zengxi Ren Bin Xu Yunhe Zhang Jing Chen Bo Yang
Publish Date: 2015/07/31
Volume: 36, Issue: 5, Pages: 639-645
Abstract
Traumatic brain injury TBI remains a significant clinical problem and contributes to onethird of all injuryrelated deaths Activated microgliamediated inflammatory response is a distinct characteristic underlying pathophysiology of TBI Here we evaluated the effect and possible mechanisms of the selective Sigma1 receptor agonist 24morpholinethyl1phenylcyclohexanecarboxylate PRE084 in mice TBI model A single intraperitoneal injection 10 μg/g PRE084 given 15 min after TBI significantly reduced lesion volume lessened brain edema attenuated modified neurological severity score increased the latency time in wire hang test and accelerated body weight recovery Moreover immunohistochemical analysis with Iba1 staining showed that PRE084 lessened microglia activation Meanwhile PRE084 reduced nitrosative and oxidative stress to proteins Thus Sigma1 receptors play a major role in inflammatory response after TBI and may serve as useful target for TBI treatment in the futureThis study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences XDA01030300 211 Projectphase III of Zhengzhou Universitythe basic and clinical research of stem cells Excellent Youth Foundation of Henan Scientific Committee 114100510005 Young Excellent Teachers in University Funded Projects of Henan Province and Bureau of Science and Technology Development Project from Henan Province 200902310250
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