Journal Title
Title of Journal: Cell Mol Neurobiol
|
Abbravation: Cellular and Molecular Neurobiology
|
|
|
|
|
|
|
|
Authors: Carlos Clayton Torres Aguiar Anália Barbosa Almeida Paulo Victor Pontes Araújo Germana Silva Vasconcelos Edna Maria Camelo Chaves Otoni Cardoso do Vale Danielle Silveira Macêdo Luzia Kalyne Almeida Moreira Leal Glauce Socorro de Barros Viana Silvânia Maria Mendes Vasconcelos
Publish Date: 2013/06/26
Volume: 33, Issue: 6, Pages: 825-835
Abstract
Agomelatine is a novel antidepressant drug with melatonin receptor agonist and 5HT2C receptor antagonist properties We analyzed whether agomelatine has antioxidant properties Antioxidant activity of agomelatine 25 50 or 75 mg/kg ip or melatonin 50 mg/kg was investigated by measuring lipid peroxidation levels nitrite content and catalase activities in the prefrontal cortex striatum and hippocampus of Swiss mice pentylenetetrazole PTZ 85 mg/kg ip pilocarpine 400 mg/kg ip picrotoxin PTX 7 mg/kg ip or strychnine 75 mg/kg ip induced seizure models In the pilocarpineinduced seizure model all dosages of agomelatine or melatonin showed a significant decrease in TBARS levels and nitrite content in all brain areas when compared to controls In the strychnineinduced seizure model all dosages of agomelatine and melatonin decreased TBARS levels in all brain areas and agomelatine at low doses 25 or 50 mg/kg and melatonin decreased nitrite contents but only agomelatine at 25 or 50 mg/kg showed a significant increase in catalase activity in three brain areas when compared to controls Neither melatonin nor agomelatine at any dose have shown no antioxidant effects on parameters of oxidative stress produced by PTX or PTZinduced seizure models when compared to controls Our results suggest that agomelatine has antioxidant activity as shown in strychnine or pilocarpineinduced seizure models
Keywords:
.
|
Other Papers In This Journal:
- VEGF-A 165 Potently Induces Human Blood–Nerve Barrier Endothelial Cell Proliferation, Angiogenesis, and Wound Healing In Vitro
- Sigma-1 Receptor Modulates Neuroinflammation After Traumatic Brain Injury
- Age and Sex Dependent Alteration in Presenilin Expression in Mouse Cerebral Cortex
- Shengmai Formula Ameliorates Pathological Characteristics in AD C. elegans
- Critical Roles of Voltage-Dependent Sodium Channels in the Process of Synaptogenesis During the Postnatal Cortical Development of Rats
- Feedback Regulation of SREBP and Aromatase in A β(25-35)-Supplemented Human Neuroblastoma Cells
- Reversal of Beta-Amyloid-Induced Neurotoxicity in PC12 Cells by Curcumin, the Important Role of ROS-Mediated Signaling and ERK Pathway
- Bradykinin Postconditioning Protects Pyramidal CA1 Neurons Against Delayed Neuronal Death in Rat Hippocampus
- Olfactory Ensheathing Cell-Conditioned Medium Reverts Aβ 25–35 -Induced Oxidative Damage in SH-SY5Y Cells by Modulating the Mitochondria-Mediated Apoptotic Pathway
- Deferoxamine Preconditioning of Neural-Like Cells Derived from Human Wharton’s Jelly Mesenchymal Stem Cells as a Strategy to Promote Their Tolerance and Therapeutic Potential: An In Vitro Study
- Introduction to Extracellular Vesicles: Biogenesis, RNA Cargo Selection, Content, Release, and Uptake
- Up-Regulation of Glis2 Involves in Neuronal Apoptosis After Intracerebral Hemorrhage in Adult Rats
- Development of the New Group of Indole-Derived Neuroprotective Drugs Affecting Oxidative Stress
- The Distinct Role of ADAM17 in APP Proteolysis and Microglial Activation Related to Alzheimer’s Disease
- Piperine Reverses Chronic Unpredictable Mild Stress-Induced Behavioral and Biochemical Alterations in Rats
- Regulation of Sirtuin 3-Mediated Deacetylation of Cyclophilin D Attenuated Cognitive Dysfunction Induced by Sepsis-Associated Encephalopathy in Mice
- The Cdk5 Kinase Downregulates ATP-Gated Ionotropic P2X 3 Receptor Function Via Serine Phosphorylation
- Immunohistochemical Study of Postnatal Neurogenesis After Whole-body Exposure to Electromagnetic Fields: Evaluation of Age- and Dose-Related Changes in Rats
- Identification of Endophilins 1 and 3 as Selective Binding Partners for VGLUT1 and Their Co-Localization in Neocortical Glutamatergic Synapses: Implications for Vesicular Glutamate Transporter Trafficking and Excitatory Vesicle Formation
- Protective Effects of UCF-101 on Cerebral Ischemia–Reperfusion (CIR) is Depended on the MAPK/p38/ERK Signaling Pathway
- The Effects of Volatile Anesthetics on the Extracellular Accumulation of [ 3 H]GABA in Rat Brain Cortical Slices
- Neurological Damage in MSUD: The Role of Oxidative Stress
- Elevated S100B and Neuron Specific Enolase Levels in Patients with Migraine-without Aura: Evidence for Neurodegeneration?
- Investigation of Long Non-coding RNA Expression Profiles in the Substantia Nigra of Parkinson’s Disease
- Cellular Neoplastic Transformation Induced by 916 MHz Microwave Radiation
- Effects of the Chinese Traditional Prescription Xiaoyaosan Decoction on Chronic Immobilization Stress-induced Changes in Behavior and Brain BDNF, TrkB, and NT-3 in Rats
- Alterations Induced by Ischemic Preconditioning on Secretory Pathways Ca 2+ -ATPase (SPCA) Gene Expression and Oxidative Damage After Global Cerebral Ischemia/Reperfusion in Rats
- Sequences of the Non-Coding RNA, NTAB, are Contained within the 3′-UTR of Human and Rat EAAT2/GLT-1 Transcripts and Act as Transcriptional Enhancers
- Modulation of Notch Signaling Pathway to Prevent H 2 O 2 /Menadione-Induced SK-N-MC Cells Death by EUK134
|