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Title of Journal: Cell Mol Neurobiol

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Abbravation: Cellular and Molecular Neurobiology

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Springer US

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DOI

10.1016/0017-9310(73)90200-7

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1573-6830

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UpRegulation of Glis2 Involves in Neuronal Apopto

Authors: Kaifu Ke Yan Song Jiabing Shen Mu Niu Haiyan Zhang Daming Yuan Haidan Ni Yu Zhang Xiaorong Liu Aihua Dai Maohong Cao
Publish Date: 2014/11/05
Volume: 35, Issue: 3, Pages: 345-354
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Abstract

The novel Krüppellike zinc finger protein Glisimilar 2 Glis2 one member of the transcription factors is involved in controlling the flow of genetic information and the modulation of diverse cellular activities Accumulating evidence has demonstrated its important roles in adult development and several diseases However information regarding the regulation and possible function of Glis2 in the central nervous system is still limited In this study we explored the roles of Glis2 during the pathophysiological process of intracerebral hemorrhage ICH An ICH rat model was established and assessed by behavioral tests Expression of Glis2 was significantly upregulated in brain areas surrounding the hematoma following ICH Immunofluorescence showed that Glis2 was strikingly increased in neurons but not astrocytes or microglia Upregulation of Glis2 was found to be accompanied by the increased expression of active caspase3 and Bax and decreased expression of Bcl2 in vivo and vitro studies Moreover knocking down Glis2 by RNAinterference in PC12 cells reduced active caspase3 and Bax expression while increased Bcl2 Collectively we speculated that Glis2 might exert proapoptotic function in neurons following ICH

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