Journal Title
Title of Journal: Cell Mol Neurobiol
|
Abbravation: Cellular and Molecular Neurobiology
|
|
|
|
|
|
|
|
Authors: Weimin Zhang Dejuan Zhi Hui Ren Dong Wang Xin Wang Zhanxin Zhang Dongqing Fei Hongmei Zhu Hongyu Li
Publish Date: 2016/02/17
Volume: 36, Issue: 8, Pages: 1291-1302
Abstract
Shengmai SM formula a classical traditional Chinese medicine formula is composed of Panax ginseng Pg Ophiopogon japonicus Oj and Schisandra Chinesis Sc SM has been clinically used to treat heart failure and ischemic heart disease Although SM formula has been reported to be potential for fighting against Alzheimer’s disease AD by previous works there are many gaps in our knowledge on its usage in AD treatment on an organism level and will then need to be further clarified In this study transgenic Caenorhabditis elegans expressing human Aβ1–42 are used to evaluate SM formula efficacy to treat AD phenotype and to investigate its underlying mechanism The results showed that SM formula ameliorated AD pathological characteristics of paralysis behavior and chemotaxis defect in transgenic C elegans With SM treatment the number of Aβ deposits decreased the levels of gene expressions of hsp162 hsp1641 ace1 ace2 and TNFA1P1 homolog genes were downregulated Our results also showed that Oj exhibited more stronger effect on delaying paralysis in worms than Pg and Sc did and synergistic action was observed between Pg and Oj and Sc further enhanced the activity of Pg/Oj combination on delaying paralysis behavior Further SM with herbs of Pg Oj and Sc at a dose proportion of 996 exhibited superior therapeutic efficacy in comparison with herbs at other dose proportions After SM formula extracted by ethanol it delayed AD symptoms on a wider dose from 02 to 100 mg/mL with no toxic effect These results provided more evidence for SM formula being potential to be used to treat ADThis work was supported by the special grand national sciencetechnology project 2015ZX09501004003008 The national natural science foundation of China 31560176 The Fundamental Research Funds for the Central Universities of China lzujbky2014149 lzujbky201375 Nematode strains used in this work were provided by the CGC which is funded by NIH Office of Research Infrastructure Programs P40 OD010440
Keywords:
.
|
Other Papers In This Journal:
- VEGF-A 165 Potently Induces Human Blood–Nerve Barrier Endothelial Cell Proliferation, Angiogenesis, and Wound Healing In Vitro
- Sigma-1 Receptor Modulates Neuroinflammation After Traumatic Brain Injury
- Age and Sex Dependent Alteration in Presenilin Expression in Mouse Cerebral Cortex
- Critical Roles of Voltage-Dependent Sodium Channels in the Process of Synaptogenesis During the Postnatal Cortical Development of Rats
- Feedback Regulation of SREBP and Aromatase in A β(25-35)-Supplemented Human Neuroblastoma Cells
- Reversal of Beta-Amyloid-Induced Neurotoxicity in PC12 Cells by Curcumin, the Important Role of ROS-Mediated Signaling and ERK Pathway
- Bradykinin Postconditioning Protects Pyramidal CA1 Neurons Against Delayed Neuronal Death in Rat Hippocampus
- Olfactory Ensheathing Cell-Conditioned Medium Reverts Aβ 25–35 -Induced Oxidative Damage in SH-SY5Y Cells by Modulating the Mitochondria-Mediated Apoptotic Pathway
- Deferoxamine Preconditioning of Neural-Like Cells Derived from Human Wharton’s Jelly Mesenchymal Stem Cells as a Strategy to Promote Their Tolerance and Therapeutic Potential: An In Vitro Study
- Introduction to Extracellular Vesicles: Biogenesis, RNA Cargo Selection, Content, Release, and Uptake
- Up-Regulation of Glis2 Involves in Neuronal Apoptosis After Intracerebral Hemorrhage in Adult Rats
- Development of the New Group of Indole-Derived Neuroprotective Drugs Affecting Oxidative Stress
- The Distinct Role of ADAM17 in APP Proteolysis and Microglial Activation Related to Alzheimer’s Disease
- Piperine Reverses Chronic Unpredictable Mild Stress-Induced Behavioral and Biochemical Alterations in Rats
- Regulation of Sirtuin 3-Mediated Deacetylation of Cyclophilin D Attenuated Cognitive Dysfunction Induced by Sepsis-Associated Encephalopathy in Mice
- The Cdk5 Kinase Downregulates ATP-Gated Ionotropic P2X 3 Receptor Function Via Serine Phosphorylation
- Immunohistochemical Study of Postnatal Neurogenesis After Whole-body Exposure to Electromagnetic Fields: Evaluation of Age- and Dose-Related Changes in Rats
- Identification of Endophilins 1 and 3 as Selective Binding Partners for VGLUT1 and Their Co-Localization in Neocortical Glutamatergic Synapses: Implications for Vesicular Glutamate Transporter Trafficking and Excitatory Vesicle Formation
- Protective Effects of UCF-101 on Cerebral Ischemia–Reperfusion (CIR) is Depended on the MAPK/p38/ERK Signaling Pathway
- The Effects of Volatile Anesthetics on the Extracellular Accumulation of [ 3 H]GABA in Rat Brain Cortical Slices
- Neurological Damage in MSUD: The Role of Oxidative Stress
- Elevated S100B and Neuron Specific Enolase Levels in Patients with Migraine-without Aura: Evidence for Neurodegeneration?
- Investigation of Long Non-coding RNA Expression Profiles in the Substantia Nigra of Parkinson’s Disease
- Cellular Neoplastic Transformation Induced by 916 MHz Microwave Radiation
- Effects of the Chinese Traditional Prescription Xiaoyaosan Decoction on Chronic Immobilization Stress-induced Changes in Behavior and Brain BDNF, TrkB, and NT-3 in Rats
- Alterations Induced by Ischemic Preconditioning on Secretory Pathways Ca 2+ -ATPase (SPCA) Gene Expression and Oxidative Damage After Global Cerebral Ischemia/Reperfusion in Rats
- Sequences of the Non-Coding RNA, NTAB, are Contained within the 3′-UTR of Human and Rat EAAT2/GLT-1 Transcripts and Act as Transcriptional Enhancers
- Effects of Agomelatine on Oxidative Stress in the Brain of Mice After Chemically Induced Seizures
- Modulation of Notch Signaling Pathway to Prevent H 2 O 2 /Menadione-Induced SK-N-MC Cells Death by EUK134
|