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Title of Journal: Clin Orthop Relat Res

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Abbravation: Clinical Orthopaedics and Related Research®

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Springer-Verlag

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DOI

10.1016/0002-9610(82)90160-x

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1528-1132

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Strength of Antimicrobial Bone Cement Decreases wi

Authors: Matt Nugent Alex McLaren Brent Vernon Ryan McLemore
Publish Date: 2010/02/17
Volume: 468, Issue: 8, Pages: 2101-2106
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Abstract

We therefore asked the following questions 1 Does the poragen fraction in antimicrobialloaded bone cement affect its antimicrobial release 2 Does poragen fraction in antimicrobialloaded bone cement affect its compressive strength and 3 Does the effect on compressive strength change over time in elutionAntimicrobialloaded bone cement made in the proportions of 40 g polymer powder 20 mL monomer liquid 1 g tobramycin powder and one of six different doses of poragen powder 0 1 2 4 8 or 16 g of particulate xylitol per batch was formed into standardized test cylinders and eluted for 30 days We determined the cumulative recovered tobramycin and the change in compressive strength over 30 days of elutionAntimicrobial release progressively increased with increasing poragen fraction Compressive strength progressively decreased with increasing poragen fraction and with increasing time in elution Poragen fractions greater than 2 g per batch caused the compressive strength to decrease below 70 MPa over 30 days of elutionThe use of poragens can increase elution of antimicrobials from antimicrobialloaded bone cement However for implant fixation to avoid deleterious reduction of compressive strength the amount of poragen that can be added in addition to 1 g of antimicrobial powder may be limited to 2 g per batch

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