Paper Search Console

Home Search Page About Contact

Journal Title

Title of Journal: Clin Orthop Relat Res

Search In Journal Title:

Abbravation: Clinical Orthopaedics and Related Research®

Search In Journal Abbravation:

Publisher

Springer-Verlag

Search In Publisher:

DOI

10.1016/0040-1951(82)90052-x

Search In DOI:

ISSN

1528-1132

Search In ISSN:
Search In Title Of Papers:

Emerging Ideas Can Erythromycin Reduce the Risk o

Authors: Weiping Ren David C Markel
Publish Date: 2011/05/17
Volume: 469, Issue: 8, Pages: 2399-2403
PDF Link

Abstract

Persistent inflammatory reaction to wear debris causes periprosthetic osteolysis and loosening Some authors have advocated pharmaceutical approaches to reduce the inflammatory reaction Erythromycin has antiinflammatory effects independent of its antimicrobial properties Although oral erythromycin reportedly inhibits periprosthetic tissue inflammation in patients with aseptic loosening longterm systematic erythromycin treatment is not recommended owing to its side effects Therefore it would be advantageous to restrict erythromycin delivery to the inflammatory periprosthetic tissue without causing side effectsWe propose restricting erythromycin delivery to the inflammatory periprosthetic site A previously described rat model of ultrahigh molecular weight polyethylene UHMWPE particleinduced periprosthetic tissue inflammation and osteolysis will be used to test the effect of local delivery of erythromycin via PeriApatiteTMcoated Ti implants The outcome measures will include bone ingrowth μCT implant stability pullout test and histologic analysis of periprosthetic tissuesPharmacologic intervention aimed at slowing preventing or reversing the aseptic loosening process would represent an advance in the management of joint replacement Erythromycin may be appropriate for prophylactically treating patients who have repeated revision surgery and/or show early signs of progressive osteolysis after arthroplasty

Keywords:

References

.
Search In Abstract Of Papers:
Other Papers In This Journal:
  1. Sterility of the Personal Protection System in Total Joint Arthroplasty
  2. Plain Radiographs Underestimate the Asymmetry of the Posterior Condylar Offset of the Knee Compared With MRI
  3. Functional Restoration of Critically Sized Segmental Defects With Bone Morphogenetic Protein-2 and Heparin Treatment
  4. Intraoperative Radiographs for Placing Acetabular Components in Hip Resurfacing Arthroplasty
  5. The Minimum Clinically Important Difference of the Patient-rated Wrist Evaluation Score for Patients With Distal Radius Fractures
  6. CORR Insights ® : Trabecular Metal in Total Knee Arthroplasty Associated with Higher Knee Scores: A Randomized Controlled Trial
  7. Survival in Mesenchymal Chondrosarcoma Varies Based on Age and Tumor Location: A Survival Analysis of the SEER Database
  8. CORR Insights ® : Are PEEK-on-Ceramic Bearings an Option for Total Disc Arthroplasty? An In Vitro Tribology Study
  9. Physician Competence and Skill Part I: The Role of Hospital Corporate Liability
  10. Better Function for Fusions Versus Above-the-knee Amputations for Recurrent Periprosthetic Knee Infection
  11. Tendinosis-like Histologic and Molecular Changes of the Achilles Tendon to Repetitive Stress: A Pilot Study in Rats
  12. Orthopaedic Education in the United Kingdom
  13. What is the Survivorship of Fully Coated Femoral Components in Revision Hip Arthroplasty?
  14. Classifications In Brief: The Paprosky Classification of Femoral Bone Loss
  15. How Does TKA Kinematics Vary With Transverse Plane Alignment Changes in a Contemporary Implant?
  16. Letter to the Editor: Increased Anteversion of Press-Fit Femoral Stems Compared with Anatomic Femur
  17. Editorial: Words Hurt – Avoiding Dehumanizing Language in Orthopaedic Research and Practice
  18. Elderly Patients Have Similar Outcomes Compared to Younger Patients After Minimally Invasive Surgery for Spinal Stenosis
  19. How Reliable Is the Alpha-defensin Immunoassay Test for Diagnosing Periprosthetic Joint Infection? A Prospective Study
  20. Prior Use of Antimicrobial Therapy is a Risk Factor for Culture-negative Prosthetic Joint Infection
  21. Ceramic-on-ceramic THA Implants in Patients Younger Than 20 Years
  22. The Usefulness of VEPTR in the Older Child With Complex Spine and Chest Deformity
  23. Corrosion at the Cone/Taper Interface Leads to Failure of Large-diameter Metal-on-metal Total Hip Arthroplasties
  24. Bone Stress Injuries Are Common in Female Military Trainees: A Preliminary Study
  25. Recurrent Giant Cell Tumor of Long Bones: Analysis of Surgical Management
  26. Is ORIF Superior to Nonoperative Treatment in Isolated Displaced Partial Articular Fractures of the Radial Head?
  27. Has the Level of Evidence of Podium Presentations at the Musculoskeletal Tumor Society Annual Meeting Changed Over Time?
  28. Do Oxidized Zirconium Femoral Heads Reduce Polyethylene Wear in Cemented THAs? A Blinded Randomized Clinical Trial
  29. Classifications in Brief: Lauge-Hansen Classification of Ankle Fractures
  30. Strength of Antimicrobial Bone Cement Decreases with Increased Poragen Fraction
  31. High Medium-term Survival of Zweymüller SLR-Plus ® Stem Used in Femoral Revision
  32. Guest Editorial: Perioperative Pain Management in Orthopaedic Surgery: Editorial Comment
  33. Nonoperative Treatment of an Os Peroneum Fracture in a High-level Athlete: A Case Report
  34. Do Jumbo Cups Cause Hip Center Elevation in Revision THA? A Computer Simulation
  35. Statistics In Brief: When to Use and When Not to Use a Threshold P Value
  36. How Does Bone Quality Differ Between Healthy-weight and Overweight Adolescents and Young Adults?
  37. Children with Spina Bifida are at Risk for Low Bone Density
  38. Slipped Capital Femoral Epiphysis: Relevant Pathophysiological Findings With Open Surgery
  39. Biographical Sketch: William Russell MacAusland, MD 1882–1965
  40. Association of a Modified Frailty Index With Mortality After Femoral Neck Fracture in Patients Aged 60 Years and Older
  41. Radiographic Risk Factors for Labral Lesions in Femoroacetabular Impingement
  42. Does Sclerostin Depletion Stimulate Fracture Healing in a Mouse Model?
  43. Letter to the Editor: Is There Really No Benefit of Vertebroplasty for Osteoporotic Vertebral Fractures? A Meta-analysis
  44. Indications for Reverse Total Shoulder Arthroplasty in Rotator Cuff Disease
  45. Case Report: Curetting Osteoid Osteoma of the Spine Using Combined Video-assisted Thoracoscopic Surgery and Navigation
  46. Do “Premium” Joint Implants Add Value?: Analysis of High Cost Joint Implants in a Community Registry
  47. Introducing a Knee Endoprosthesis Model Increases Risk of Early Revision Surgery
  48. Backside Wear Is Not Dependent on the Acetabular Socket Design in Crosslinked Polyethylene Liners
  49. Total Ankle Replacement Compatible with Ligament Function Produces Mobility, Good Clinical Scores, and Low Complication Rates: An Early Clinical Assessment
  50. The Classic: The Iliac Apophysis: An Invaluable Sign in the Management of Scoliosis
  51. One-year Patient-reported Outcomes After Arthroscopic Rotator Cuff Repair Do Not Correlate With Mild to Moderate Psychological Distress
  52. Does a Microprocessor-controlled Prosthetic Knee Affect Stair Ascent Strategies in Persons With Transfemoral Amputation?
  53. Hip Injuries in the Overhead Athlete
  54. Is Stability of the Proximal Tibiofibular Joint Important in the Multiligament-injured Knee?
  55. Single- versus Double-bundle ACL Reconstruction: Is There Any Difference in Stability and Function at 3-year Followup?
  56. The Prevalence of Groin Pain After Metal-on-Metal Total Hip Arthroplasty and Total Hip Resurfacing
  57. Case Report: Fibroxanthoma: A Complication of a Biodegradable Screw
  58. Midterm Assessment of Causes and Results of Revision Total Knee Arthroplasty
  59. Do Joint Registries Report True Rates of Hip Dislocation?
  60. Is Routine Mid-term Total Hip Arthroplasty Surveillance Beneficial?
  61. The Role of Ultrasound in Clubfoot Treatment: Correlation with the Pirani Score and Assessment of the Ponseti Method
  62. CORR Insights ® : Fractures in Geriatric Mice Show Decreased Callus Expansion and Bone Volume
  63. Structure-Respiration Function Relationships Before and After Surgical Treatment of Early-onset Scoliosis
  64. Psychological Distress Negatively Affects Self-assessment of Shoulder Function in Patients With Rotator Cuff Tears
  65. Salvage of Failed Acetabular Cages by Nonbuttressed Trabecular Metal Cups
  66. Letter to the Editor: The Oblique Anterolateral Approach to the Lumbar Spine Provides Access to the Lumbar Spine With Few Early Complications
  67. Assessing Readability of Patient Education Materials: Current Role in Orthopaedics
  68. Is Helical Blade Nailing Superior to Locked Minimally Invasive Plating in Unstable Pertrochanteric Fractures?
  69. CORR Insights ® : Does the Utilization of Allograft Tissue in Medial Patellofemoral Ligament Reconstruction in Pediatric and Adolescent Patients Restore Patellar Stability?
  70. Giants of Orthopaedic Surgery: Richard J. Smith MD
  71. CORR Insights ® : Labral Reattachment in Femoroacetabular Impingement Surgery Results in Increased 10-year Survivorship Compared With Resection
  72. CORR Insights ® : What Factors Are Associated With Failure of Compressive Osseointegration Fixation?
  73. Promising Mid-term Results With a Cup-cage Construct for Large Acetabular Defects and Pelvic Discontinuity
  74. Intraarticular Analgesia Versus Epidural Plus Femoral Nerve Block After TKA: A Randomized, Double-blind Trial
  75. Cochrane in CORR ® : Continuous Passive Motion Following Total Knee Arthroplasty in People With Arthritis (Review)
  76. Pearls: How to Place an Interposition Segmental Bone Block for Lengthening or Alignment
  77. Does Open Reduction and Internal Fixation versus Primary Arthrodesis Improve Patient Outcomes for Lisfranc Trauma? A Systematic Review and Meta-analysis
  78. Does Ultrasound Correlate with Surgical or Histologic Findings in Greater Trochanteric Pain Syndrome? A Pilot Study
  79. CORR Insights ® : What Are the 30-day Readmission Rates Across Orthopaedic Subspecialties?
  80. Randomized Trial of Hemiarthroplasty versus Internal Fixation for Femoral Neck Fractures: No Differences at 6 Years
  81. Validation of the Korean Version of the Oxford Knee Score in Patients Undergoing Total Knee Arthroplasty
  82. Office-based Core Needle Biopsy of Bone and Soft Tissue Malignancies: An Accurate Alternative to Open Biopsy with Infrequent Complications
  83. Is There Variation in Procedural Utilization for Lumbar Spine Disorders Between a Fee-for-Service and Salaried Healthcare System?
  84. CORR Insights ® : Two- to 4-year Followup of a Short Stem THA Construct: Excellent Fixation, Thigh Pain a Concern
Search Result: