Authors: Christa L Hoy Heather M Macdonald Heather A McKay
Publish Date: 2012/09/22
Volume: 471, Issue: 4, Pages: 1214-1225
Abstract
We categorized males n = 103 mean age 17 years and females n = 85 mean age 18 years into healthyweight and overweight groups We measured lean mass LM and fat mass FM with dualenergy xray absorptiometry DXA We used highresolution peripheral quantitative CT to assess the distal radius 7 site and distal tibia 8 site Bone quality measures included total bone mineral density TtBMD total area TtAr trabecular bone volume fraction BV/TV trabecular number TbN separation TbSp and thickness TbTh We used multiple regression to compare bone quality between healthyweight and overweight adolescents adjusting for age ethnicity limb length LM and FMOverweight males had higher 10–21 TtBMD BV/TV and TbN and lower TbSp at the tibia and lower TtAr at the radius than healthyweight males No differences were observed between overweight and healthyweight females LM attenuated the differences in bone quality between groups in males while FM negatively predicted TtBMD BV/TV TbN and TbThOur data suggest overweight males have enhanced bone quality compared with healthyweight males however when group differences are interpreted in the context of the mechanostat theory it appears bone quality of overweight adolescents adapts to LM and not to greater FMEach author certifies that his or her institution approved the human protocol for this investigation that all investigations were conducted in conformity with ethical principles of research and that informed consent for participation in the study was obtainedWe thank the many members of the Healthy Bones Research team whose ideas and hard work contributed to the design and implementation of the Healthy Bones studies over the years especially Kerry MacKelvieO’Brien PhD Moira Petit PhD Deetria Egeli BHSc and Sarah Moore MSc We are blessed with skilled and knowledgeable research staff and acknowledge the key contribution of Danmei Liu PhD to the medical imaging of bone and to Douglas Race MA and his measurement team for acquisition of anthropometry and other data Without the ongoing and sustained support of schools in Vancouver and Richmond in British Columbia which are key partners in this research we would be unable to conduct our studies Finally we owe a huge debt of gratitude to the boys and girls now young men and women who participated in the Healthy Bones trials over the last decade
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