Authors: A Egli C Bucher A Dumoulin M Stern A Buser L Bubendorf M Gregor P Servida G Sommer J Bremerich A Gratwohl N Khanna A F Widmer M Battegay M Tamm H H Hirsch J P Halter
Publish Date: 2012/07/18
Volume: 40, Issue: 6, Pages: 677-684
Abstract
The clinical characteristics of human metapneumovirus hMPVassociated lower respiratory tract infection LRTI after allogeneic hematopoietic stem cell transplantation HSCT is not well described We describe the clinical course in eight HSCT recipients suffering from hMPV infectionEight patients with hMPVassociated LRTI were identified from 93 BAL samples Three of the eight patients had coinfections with other pathogens The median age of the patients was 45 years interquartile range IQR 368–535 the median time posttransplant was 473 days IQR 251–1165 5/8 patients had chronic graftversushost disease cGvHD and 6/8 patients received immunosuppression Chest computed tomography CT scanning showed a groundglass pattern in 7/8 patients Seven of eight patients required hospitalization due to severe symptoms and hypoxemia All were treated with intravenous immunoglobulin IVIG which was combined with oral ribavirin in six patients The mortality rate was 125 1/8
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