Authors: L de Vedia A Arechavala M I Calderón E Maiolo A Rodríguez N Lista E Di Virgilio J C Cisneros R Prieto
Publish Date: 2013/10/14
Volume: 41, Issue: 6, Pages: 1073-1077
Abstract
This was an observational retrospective study Patients were treated according to the Infectious Diseases Society of America recommendations during the evaluation period days 0 3 5 and after hospitalization High intracranial pressure HICP was defined as ICP values of ≥250 mm H20 The correlation between HICP and mortality at each of the three time points considered was investigated Statistical analysis on the descriptive parameters and on the probability of a “death” event odds ratio OR at each of those three time points was performed using the statistical software program EpidataEighty patients were included in this study of whom 53 6625 were male The average age of the patients was 375 ± 81 range 22–55 years The median CD4+ lymphocyte cell count was 35 range 0–367 cells/ml Among the entire patient cohort 53 patients had a favorable outcome and the mortality rate was 3375 At baseline day 0 57 subjects 715 presented HICP and these patients had a higher mortality rate than those with a normal ICP but the difference did not reach statistical significance OR 165 95 confidence interval CI 056–484 On day 3 41 of the patients presented HICP and HICP at this time point was significantly associated with an increased risk of mortality OR 435 95 CI 156–1209 On day 5 35 435 patients presented HICP and HCIP at this time point was also significantly associated with higher mortality OR 723 95 CI 253–2014
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