Authors: R Leistner S Gürntke C Sakellariou L A Denkel A Bloch P Gastmeier F Schwab
Publish Date: 2014/08/07
Volume: 42, Issue: 6, Pages: 991-997
Abstract
The burden of extendedspectrum betalactamase ESBLpositive Enterobacteriaceae ESBLE is growing worldwide We aimed to determine the financial disease burden attributable to ESBLpositive species in cases of bloodstream infection BSI due to K pneumoniae and E coliWe conducted a cohort study on patients with BSI due to K pneumoniae or E coli between 2008 and 2011 in our institution Data were collected on true hospital costs length of stay LOS basic demographic parameters underlying diseases as Charlson comorbidity index CCI and ESBL positivity of the pathogens Multivariable regression analysis on hospital costs and length of stay was performedOverall we found 1851 consecutive cases of ESBLE BSI 352 190 cases of K pneumoniae BSI and 1499 810 cases of E coli BSI Sixtysix of E coli BSI 188 and 178 of K pneumoniae BSI 119 cases were due to ESBLpositive isolates respectively p = 0001 830 448 cases were hospitalonset 215 611 of the K pneumoniae and 615 410 of the E coli cases p 0001 Inhospital mortality was overall 198 250 in K pneumoniae cases and 185 in E coli cases p = 0006 Increased hospital costs and length of stay were significantly associated to BSI with ESBLpositive K pneumoniae
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