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Title of Journal: Infection

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Abbravation: Infection

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Springer Berlin Heidelberg

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DOI

10.1007/bf02673215

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ISSN

1439-0973

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Intrathecal/intraventricular colistin in external

Authors: O Bargiacchi A Rossati P Car D Brustia R Brondolo F Rosa P L Garavelli F G De Rosa
Publish Date: 2014/04/12
Volume: 42, Issue: 5, Pages: 801-809
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Abstract

We report three cases of external ventricular derivation infections caused by multidrugresistant Gramnegative rods and treated successfully with intraventricular colistin The intrathecal or intraventricular use of colistin have been reported in more than 100 cases without any consensus on dosage duration and type monotherapy or combination therapy of treatment Based on our comprehensive review of the relevant literature relating to both clinical and pharmacokinetic data we conclude that the intrathecal/intraventricular administration of colistin is a safe and effective option to treat central nervous system infections caused by multidrugresistant Gramnegative bacteria

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