Authors: Sheng Tong Thomas J Cradick Yan Ma ZhiFei Dai Gang Bao
Publish Date: 2012/10/31
Volume: 55, Issue: 10, Pages: 843-861
Abstract
Nanomedicine is an emerging field that integrates nanotechnology biomolecular engineering life sciences and medicine it is expected to produce major breakthroughs in medical diagnostics and therapeutics Due to the sizecompatibility of nanoscale structures and devices with proteins and nucleic acids the design synthesis and application of nanoprobes nanocarriers and nanomachines provide unprecedented opportunities for achieving a better control of biological processes and drastic improvements in disease detection therapy and prevention Recent advances in nanomedicine include the development of functional nanoparticle based molecular imaging probes nanostructured materials as drug/gene carriers for in vivo delivery and engineered molecular machines for treating singlegene disorders This review focuses on the development of molecular imaging probes and engineered nucleases for nanomedicine including quantum dot bioconjugates quantum dotfluorescent protein FRET probes molecular beacons magnetic and gold nanoparticle based imaging contrast agents and the design and validation of zinc finger nucleases ZFNs and TAL effector nucleases TALENs for gene targeting The challenges in translating nanomedicine approaches to clinical applications are discussedThis article is published under an open access license Please check the Copyright Information section for details of this license and what reuse is permitted If your intended use exceeds what is permitted by the license or if you are unable to locate the licence and reuse information please contact the Rights and Permissions team
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