Authors: Yue Zhang YingKe Li
Publish Date: 2012/12/20
Volume: 56, Issue: 1, Pages: 13-18
Abstract
The innate immune response provides the initial defense against infection This is accomplished by families of pattern recognition receptors PRRs that bind to conserved molecules in bacteria fungi and viruses PRRs are finely regulated by elaborate mechanisms to ensure a beneficial outcome in response to foreign invaders MicroRNAs miRNAs are a class of small noncoding regulatory RNAs that are emerging as important regulators in immune responses at the posttranscriptional level through the inhibition of translation or by inducing mRNA degradation It has been shown that miRNAs have unique expression profiles in cells of the innate immune systems and play pivotal roles in regulating the signal pathways of innate receptors including Tolllike receptors RIGIlike receptors and Nodlike receptors We have summarized the recent literature providing new insights into the regulation of innate receptor pathways by miRNAsThis article is published under an open access license Please check the Copyright Information section for details of this license and what reuse is permitted If your intended use exceeds what is permitted by the license or if you are unable to locate the licence and reuse information please contact the Rights and Permissions team
Keywords: