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Title of Journal: Sci China Life Sci

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Abbravation: Science China Life Sciences

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Science China Press

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DOI

10.1007/978-1-59745-366-0_27

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1869-1889

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T2 relaxation time measurements in the brains of s

Authors: Tao Jiang Liqi Xie Xin Lou Dawei Li Zhiye Chen Huafeng Xiao Lin Ma
Publish Date: 2017/01/04
Volume: 60, Issue: 1, Pages: 5-10
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Abstract

This study aimed to evaluate the T2 relaxation time of the brain in severely scalded rats using a magnetic resonance MR T2 mapping sequence and to investigate the correlation between T2 relaxation time and plasma glucose level Twentyeight Wistar rats were randomly divided into the scalded group n=21 and control group n=7 Magnetic resonance scans were performed with T1WI T2WI and T2mapping sequences in the scalded group the scans were performed 1 day prior to scalding and 1 3 5 and 7 days postscalding in addition identical MR scans were performed in the control group at the same time points T2maps were generated and T2 relaxation times were acquired from the following brain regions the hippocampus thalamus caudateputamen and cerebrum Pathological changes of the hippocampus were observed The plasma glucose level of each rat was measured before each MR scan and a correlation analysis was performed between T2 relaxation time and plasma glucose level We found that conventional T1WI and T2WI did not reveal any abnormal signals or morphological changes in the hippocampus thalamus caudateputamen or cerebrum postscalding Both the T2 relaxation times of the selected brain regions and plasma glucose levels increased 1 3 and 5 days postscalding and returned to normal levels 7 days postscalding The most marked increase of T2 relaxation time was found in the hippocampus similar changes were also revealed in the thalamus caudateputamen and cerebrum No correlation was found between T2 relaxation time and plasma glucose level in scalded rats Pathological observation of the hippocampus showed edema 1 3 and 5 days postscalding with recovery to normal findings at 7 days postscalding Thus we concluded that T2 mapping is a sensitive method for detecting and monitoring scald injury in the rat brain As the hippocampus is the main region for modulating a stress reaction it showed significantly increased water content along with an increased plasma glucose level postscalding

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