Authors: Beata Smolarz Jan Wilczyński Dorota Nowakowska
Publish Date: 2014/11/01
Volume: 60, Issue: 3, Pages: 199-209
Abstract
Herpesvirus infections such as those induced by human cytomegalovirus HCMV induce specific DNA damages DNA damages can lead to cell mutation death apoptosis and immune system activation Various types of DNA damage are repaired through multiple repair pathways such as base excision nucleotide excision homologous recombination and nonhomologous end joining Changes in the activity of DNA repair proteins during viral infection can cause disturbances in the DNA repair system and change its mechanisms This report reviews results from studies assaying a DNA repair system in HCMV infectionDNA damage normally triggers activities of the cellular DNA repair machinery There are six known systems of DNA repair pathway of direct reversion of damage base excision repair BER nucleotideexcision repair NER mismatch repair MMR homologous recombination HR and nonhomologous DNA end joining NHEJ Unrepaired DNA damage can lead to mutation development of various diseases or cell death Bartek et al 2004 Jackson and Bartek 2009 Hoeijmakers 2009 Polo and Jackson 2011Many studies have analysed cell repair capabilities following viral infection Those experimental studies focused on repairs of exogenously introduced damage in cellular DNA in the context of single viral protein expression Becker et al 1998 Prost et al 1998 Groisman et al 1999 Jia et al 1999 Chipitsyna et al 2004 Mathonnet et al 2004 Liang et al 2006 Sun et al 2006 Trojanek et al 2006 Durkin et al 2008 Gruhne et al 2009 Baydoun et al 2011 and on effects of complete infection Deng et al 1992a Philpott and Buehring 1999 RannebergNilsen et al 2006 Duong et al 2010 reviewed in Lilley et al 2010 Pal et al 2010 Kulkarni and Fortunato 2011
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