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Title of Journal: Folia Microbiol

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Abbravation: Folia Microbiologica

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Springer Netherlands

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DOI

10.1002/ejoc.201500714

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1874-9356

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Current views on EmphasisHIV1/Emphasis latenc

Authors: Zora Melkova Prakash Shankaran Michaela Madlenakova Josef Bodor
Publish Date: 2016/10/05
Volume: 62, Issue: 1, Pages: 73-87
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Abstract

HIV1 infection cannot be cured as it persists in latently infected cells that are targeted neither by the immune system nor by available therapeutic approaches Consequently a lifelong therapy suppressing only the actively replicating virus is necessary The latent reservoir has been defined and characterized in various experimental models and in human patients allowing research and development of approaches targeting individual steps critical for HIV1 latency establishment maintenance and reactivation However additional mechanisms and processes driving the remaining lowlevel HIV1 replication in the presence of the suppressive therapy still remain to be identified and targeted Current approaches toward HIV1 cure involve namely attempts to reactivate and purge HIV latently infected cells socalled “shock and kill” strategy as well as approaches involving gene therapy and/or gene editing and stem cell transplantation aiming at generation of cells resistant to HIV1 This review summarizes current views and concepts underlying different approaches aiming at functional or sterilizing cure of HIV1 infectionWe are grateful to Dr Ivan Hirsch for helpful discussions and comments The work of PS and MM was performed in partial fulfillment of the requirements for PhD degree at the First Medical Faculty Charles University The work was supported by the Grant Agency of the Ministry of Health of the Czech Republic – project No NT/141353


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  1. Species identification of Campylobacter jejuni ssp. jejuni and C. coli by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and PCR
  2. Production of 3-indolylacetic acid in root nodules and culture by a Rhizobium species isolated from root nodules of the leguminous pulse Phaseolus mungo
  3. A thermo-halo-tolerant and proteinase-resistant endoxylanase from Bacillus sp. HJ14
  4. The role of procalcitonin in neonatal intensive care unit patients with candidemia
  5. Insights into the pH up-shift responsive mechanism of Acidithiobacillus ferrooxidans by microarray transcriptome profiling
  6. Aerobic biodegradation of dinitrotoluenes in batch systems by pure and mixed cultures
  7. Dynamics of predominant microbiota in the human gastrointestinal tract and change in luminal enzymes and immunoglobulin profile during high-altitude adaptation
  8. First report of Wohlfahrtiimonas chitiniclastica from soft tissue and bone infection at an unusually high northern latitude
  9. Effect of phosphate-solubilizing fungi Aspergillus awamori S29 on mungbean ( Vigna radiata cv. RMG 492) growth
  10. DNA repair mechanisms and human cytomegalovirus (HCMV) infection
  11. Enterovirulent E. coli in inflammatory and noninflammatory bowel diseases
  12. Transcriptional regulators of GntR family in Streptomyces coelicolor A3(2): analysis in silico and in vivo of YtrA subfamily
  13. Spontaneous in vitro IL-6 production in various intestinal segments in patients with inflammatory bowel disease
  14. Biofilm density and detection of biofilm-producing genes in methicillin-resistant Staphylococcus aureus strains
  15. Phenotypic and genotypic characteristics of Arcanobacterium haemolyticum isolated from clinical samples in a Danish hospital
  16. An imported case of bloody diarrhea in the Czech Republic caused by a hybrid enteroaggregative hemorrhagic Escherichia coli (EAHEC) O104:H4 strain associated with the large outbreak in Germany, May 2011
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  18. Comparison of nisin and monensin effects on ciliate and selected bacterial populations in artificial rumen

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