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Title of Journal: Pediatr Cardiol

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Abbravation: Pediatric Cardiology

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Springer-Verlag

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DOI

10.1016/0027-5107(71)90075-3

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1432-1971

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Administration of Steroids in Pediatric Cardiac Su

Authors: P Gessler V Hohl T Carrel J Pfenninger ER Schmid O Baenziger R Prètre
Publish Date: 2005/02/10
Volume: 26, Issue: 5, Pages: 595-600
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Abstract

Cardiopulmonary bypass CPB is associated with a systemic inflammatory response Prebypass steroid administration may modulate the inflammatory response resulting in improved postoperative recovery We performed a prospective study in the departments of cardiovascular surgery and pediatric intensive care medicine of two university hospitals that included 50 infants who underwent heart surgery Patients received either prednisolone 30 mg/kg added to the priming solution of the cardiopulmonary bypass circuit steroid group or no steroids nonsteroid group Clinical outcome parameters include therapy with inotropic drugs oxygenation blood lactate glucose and creatinine and laboratory parameters of inflammation include leukocytes Creactive protein and interleukin8 Postoperative recovery eg the number dosage and duration of inotropic drugs as well as oxygenation was similar in patients treated with or without steroids when corrected for the type of cardiac surgery performed After CPB there was an inflammatory reaction especially in patients with a long CPB time Postoperative plasma levels of interleukin8 were correlated with the duration of CPB time r = 062 p 0001 Administration of steroids had no significant impact on the laboratory parameters of inflammation Administration of prednisolone into the priming solution of the CPB circuit had no measurable influence on postoperative recovery and did not suppress the inflammatory responseThe authors thank all perfusionists especially E Gygax Department of Cardiovascular Surgery Inselspital Berne as well as the nurses of the pediatric intensive care units in Zurich and Berne for their cooperation This study was supported by a grant from EMDO Stiftung Zurich Switzerland

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