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Title of Journal: Pediatr Cardiol

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Abbravation: Pediatric Cardiology

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Springer-Verlag

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DOI

10.1007/s00441-003-0798-x

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1432-1971

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Initial Experience With Tadalafil in Pediatric Pul

Authors: Shinichi Takatsuki Michelle Calderbank David Dunbar Ivy
Publish Date: 2012/03/09
Volume: 33, Issue: 5, Pages: 683-688
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Abstract

This study aimed to investigate the safety tolerability and effects of tadalafil on children with pulmonary arterial hypertension PAH after transition from sildenafil or after tadalafil received as initial therapy A total of 33 pediatric patients with PAH were retrospectively evaluated Of the 33 patients 29 were switched from sildenafil to tadalafil The main reason for the change from sildenafil was oncedaily dosing The average dose of sildenafil was 34 ± 11 mg/kg/day and that of tadalafil was 10 ± 04 mg/kg/day For 14 of the 29 patients undergoing repeat catheterization statistically significant improvements were observed after transition from sildenafil to tadalafil in terms of mean pulmonary arterial pressure 532 ± 183 vs 474 ± 137 mmHg p  005 and pulmonary vascular resistance index 122 ± 70 vs 106 ± 72 Units/m2 p  005 Clinical improvement was noted for four patients treated with tadalafil as initial therapy The side effect profiles were similar for the patients who had transitioned from sildenafil to tadalafil including headache nausea myalgia nasal congestion flushing and allergic reaction Two patients discontinued tadalafil due to migraine or allergic reaction One patient receiving sildenafil had no breakthrough syncope after transition to tadalafil Tadalafil can be safely used for pediatric patients with PAH and may prevent disease progression

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  2. Transcatheter Amplatzer Occlusion and Surgical Closure of Patent Ductus Arteriosus: Comparison of Effectiveness and Costs in a Low-Income Country
  3. Assessments of Coronary Artery Visibility and Radiation Dose in Infants with Congenital Heart Disease on Cardiac 128-slice CT and on Cardiac 64-slice CT
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  6. Semi-supine Exercise Stress Echocardiography in Children and Adolescents: Feasibility and Safety
  7. Comparison of Immune Profiles in Fetal Hearts with Idiopathic Dilated Cardiomyopathy, Maternal Autoimmune-Associated Dilated Cardiomyopathy and the Normal Fetus
  8. Medication Dosing and Renal Insufficiency in a Pediatric Cardiac Intensive Care Unit: Impact of Pharmacist Consultation
  9. Time Course of Myocardial Amiodarone Uptake in the Piglet Heart Using a Chronic Animal Model
  10. Time Course of Myocardial Amiodarone Uptake in the Piglet Heart Using a Chronic Animal Model
  11. Balloon Valvuloplasty for Critical Pulmonary Valve Stenosis in a Premature Infant
  12. “Baby Heart Project”: The Italian Project for Accreditation and Quality Management in Pediatric Cardiology and Cardiac Surgery
  13. Characteristics of Hospitalizations for the Glenn Procedure in Those With Isomerism Compared to Those Without
  14. Does the Stage 16 Embryo in Hamburger–Hamilton’s “Series of Normal Stages in the Development of the Chick Embryo” Have a Potential “Conotruncal” Heart Defect?
  15. Beraprost Therapy in Children with Pulmonary Hypertension Secondary to Congenital Heart Disease
  16. Does the Stage 16 Embryo in Hamburger–Hamilton’s “Series of Normal Stages in the Development of the Chick Embryo” Have a Potential “Conotruncal” Heart Defect?
  17. Tako-Tsubo Syndrome in a 12-Year-Old Girl: Exhausted Heart, Not Broken Heart
  18. Administration of Steroids in Pediatric Cardiac Surgery: Impact on Clinical Outcome and Systemic Inflammatory Response
  19. Troponin I Elevation After Supraventricular Tachycardia in a Child with Hypertrophic Cardiomyopathy
  20. Interventions in Kawasaki Disease
  21. Maternally Inherited Hypertrophic Cardiomyopathy: A Manifestation of Mitochondrial DNA Mutations—Clinical Course in Two Families
  22. Pericardial Effusion in a Preterm Infant Resulting from Umbilical Venous Catheter Placement
  23. Clinical Improvement After Banding of a Pulmonary Branch Artery in a Symptomatic Patient with Osler–Rendu–Weber Syndrome
  24. Coarctation of the Aorta, Aortic Valvar Stenosis, and Supravalvar Aortic Stenosis with Left Coronary Artery Ostial Stenosis: Management Using a Staged Hybrid Approach
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  28. Multicenter Study of the Effectiveness of Implantable Cardioverter Defibrillators in Children and Young Adults With Heart Disease
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  35. Quantitative Ultrasound Measurement of Intima–Media Thickness of Abdominal Aorta and Common Carotid Arteries in Normal Term Newborns
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  38. Association of A Dilated Coronary Sinus in the Fetus with Actual and Apparent Coarctation of the Aorta and Diminutive Left Heart Structures
  39. Increased Incidence of Incomplete Kawasaki Disease at a Pediatric Hospital After Publication of the 2004 American Heart Association Guidelines
  40. Plastic bronchitis in children with fontan palliation: Analogue to protein losing enteropathy?
  41. Screening Newborns for Congenital Heart Disease with Pulse Oximetry: Survey of Pediatric Cardiologists
  42. Late Ventricular Potentials and QT Dispersion in Familial Dysautonomia
  43. Combined Treatment for Multiple Cardiac Defects with Interventional Techniques
  44. The Impact of Gestational Age on Resource Utilization After Open Heart Surgery for Congenital Cardiac Disease From Birth to 1 Year of Age
  45. Neurophysiological Effects of Pediatric Balloon Dilatation Procedures
  46. Inhaled Nitric Oxide Therapy in a Critically Ill Neonate with Ebstein's Anomaly
  47. Hypoplastic Left Heart Syndrome: Exploring a Paradigm Shift in Favor of Surgery
  48. Prenatal Detection of Coarctation of the Aorta in a Non-selected Population: A Prospective Analysis of 10 Years of Experience
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  50. Balloon Angioplasty for Native Aortic Coarctation in Different Anatomic Variants
  51. Pulmonary Artery Aneurysm in a Child Secondary to Infective Endarteritis
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  53. Incidence of Respiratory Disease During the First Two Years of Life in Children with Hemodynamically Significant Congenital Heart Disease in Italy: A Retrospective Study
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