Authors: Cengiz Bayram İlker Çetin Betul Tavil Nese Yarali Filiz Ekici Pamir Isık Bahattin Tunc
Publish Date: 2015/01/11
Volume: 36, Issue: 4, Pages: 862-866
Abstract
Improvement in longterm survival in patients with acute childhood leukemia has led to the need for monitorization of chemotherapyrelated morbidity and mortality This study included 60 patients with acute lymphoblastic leukemia that were in remission for at least 2 years and 30 healthy controls Systolic and diastolic function of myocardium was evaluated using conventional echocardiography and tissue Doppler imaging of the left ventricle interventricular septum and right ventricle Median age of patients was 117 years range 10–149 years and the median duration of remission was 4 years range 25–5 years All patients were treated with a low cumulative dose of adriamycin 100 mg/m2 according to the St Jude TotalXIIIA protocol The ejection fraction EF and fractional shortening were normal in the patient and control groups even though EF values were significantly lower in the patients 695 ± 23 vs 727 ± 3 P 001 Myocardial systole S m early diastole E m and late diastole A m velocities in all segments of the myocardium were significantly lower in the patient group P 001 for all segments Cardiotoxicity was noted in all segments of the myocardium in the patient group despite the fact that they were all treated with a low cumulative dose of adriamycin Based on these findings we think that there is no safe dose for anthracyclines and periodic echocardiographic evaluation of both the left and right ventricles must be performed in all patients treated with anthracyclines even at low doses
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