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Title of Journal: Pediatr Cardiol

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Abbravation: Pediatric Cardiology

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Springer-Verlag

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DOI

10.1016/0305-0491(78)90176-1

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1432-1971

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Autophagy in Cardiac Plasticity and Disease

Authors: Joseph A Hill
Publish Date: 2011/01/20
Volume: 32, Issue: 3, Pages: 282-289
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Abstract

The heart is a highly plastic organ In response to the physiological stress of normal life as well as the pathological stress of disease the myocardium manifests robust and rapid changes in mass In the context of diseaseassociated stress this myocardial remodeling response can culminate in ventricular thinning mechanical dysfunction and a clinical syndrome of heart failure Recently autophagy a process of cellular cannibalization has been implicated in many of these remodeling reactions In some settings the autophagic response is beneficial and prosurvival in other contexts it is maladaptive and promotes disease progression Together these observations raise the intriguing prospect of targeting maladaptive autophagy and advancing cell survivalpromoting adaptive autophagy to benefit patients with heart diseaseWe are grateful to members of the Hill laboratory for valuable suggestions and comments This work was supported by grants from the National Institutes of Health NIH Grants No HL075173 HL080144 and HL090842 The American Heart Association AHA Grant No 0640084N and the AHA—Jon Holden DeHaan Foundation

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Other Papers In This Journal:
  1. Incidence of Stenotic Lesions Predicted by Acute Phase Changes in Coronary Arterial Diameter During Kawasaki Disease
  2. Transcatheter Amplatzer Occlusion and Surgical Closure of Patent Ductus Arteriosus: Comparison of Effectiveness and Costs in a Low-Income Country
  3. Assessments of Coronary Artery Visibility and Radiation Dose in Infants with Congenital Heart Disease on Cardiac 128-slice CT and on Cardiac 64-slice CT
  4. From Other Journals
  5. Maternal Smoking During Pregnancy and the Risk of Congenital Heart Defects in Offspring: A Systematic Review and Metaanalysis
  6. Semi-supine Exercise Stress Echocardiography in Children and Adolescents: Feasibility and Safety
  7. Comparison of Immune Profiles in Fetal Hearts with Idiopathic Dilated Cardiomyopathy, Maternal Autoimmune-Associated Dilated Cardiomyopathy and the Normal Fetus
  8. Medication Dosing and Renal Insufficiency in a Pediatric Cardiac Intensive Care Unit: Impact of Pharmacist Consultation
  9. Time Course of Myocardial Amiodarone Uptake in the Piglet Heart Using a Chronic Animal Model
  10. Time Course of Myocardial Amiodarone Uptake in the Piglet Heart Using a Chronic Animal Model
  11. Balloon Valvuloplasty for Critical Pulmonary Valve Stenosis in a Premature Infant
  12. “Baby Heart Project”: The Italian Project for Accreditation and Quality Management in Pediatric Cardiology and Cardiac Surgery
  13. Characteristics of Hospitalizations for the Glenn Procedure in Those With Isomerism Compared to Those Without
  14. Does the Stage 16 Embryo in Hamburger–Hamilton’s “Series of Normal Stages in the Development of the Chick Embryo” Have a Potential “Conotruncal” Heart Defect?
  15. Beraprost Therapy in Children with Pulmonary Hypertension Secondary to Congenital Heart Disease
  16. Does the Stage 16 Embryo in Hamburger–Hamilton’s “Series of Normal Stages in the Development of the Chick Embryo” Have a Potential “Conotruncal” Heart Defect?
  17. Tako-Tsubo Syndrome in a 12-Year-Old Girl: Exhausted Heart, Not Broken Heart
  18. Administration of Steroids in Pediatric Cardiac Surgery: Impact on Clinical Outcome and Systemic Inflammatory Response
  19. Troponin I Elevation After Supraventricular Tachycardia in a Child with Hypertrophic Cardiomyopathy
  20. Interventions in Kawasaki Disease
  21. Maternally Inherited Hypertrophic Cardiomyopathy: A Manifestation of Mitochondrial DNA Mutations—Clinical Course in Two Families
  22. Pericardial Effusion in a Preterm Infant Resulting from Umbilical Venous Catheter Placement
  23. Clinical Improvement After Banding of a Pulmonary Branch Artery in a Symptomatic Patient with Osler–Rendu–Weber Syndrome
  24. Coarctation of the Aorta, Aortic Valvar Stenosis, and Supravalvar Aortic Stenosis with Left Coronary Artery Ostial Stenosis: Management Using a Staged Hybrid Approach
  25. Intrauterine Beta Blockade
  26. Food and Drug Administration (FDA) Postmarket Reported Side Effects and Adverse Events Associated with Pulmonary Hypertension Therapy in Pediatric Patients
  27. Left Ventricular Noncompaction Cardiomyopathy in Pediatric Patients: A Case Series of a Clinically Heterogeneous Disease
  28. Multicenter Study of the Effectiveness of Implantable Cardioverter Defibrillators in Children and Young Adults With Heart Disease
  29. Serum Alkaline Phosphatase Reflects Post-Fontan Hemodynamics in Children
  30. Pediatric Cardiology: Pediatrics or Cardiology?
  31. From Other Journals
  32. Pulmonary Atresia with Intact Ventricular Septum Coexisting with Coarctation of the Aorta
  33. Initial Experience with the Nit-Occlud ASD-R: Short-Term Results
  34. Echocardiographic Measurements of Cardiac Dimensions Correlate Better With Body Length Than With Body Weight or Body Surface Area
  35. Quantitative Ultrasound Measurement of Intima–Media Thickness of Abdominal Aorta and Common Carotid Arteries in Normal Term Newborns
  36. Abnormal Circumferential Strain is Present in Young Duchenne Muscular Dystrophy Patients
  37. Juxtaposition of the Atrial Appendages: A Clinical Series of 22 Patients
  38. Association of A Dilated Coronary Sinus in the Fetus with Actual and Apparent Coarctation of the Aorta and Diminutive Left Heart Structures
  39. Increased Incidence of Incomplete Kawasaki Disease at a Pediatric Hospital After Publication of the 2004 American Heart Association Guidelines
  40. Plastic bronchitis in children with fontan palliation: Analogue to protein losing enteropathy?
  41. Screening Newborns for Congenital Heart Disease with Pulse Oximetry: Survey of Pediatric Cardiologists
  42. Late Ventricular Potentials and QT Dispersion in Familial Dysautonomia
  43. Combined Treatment for Multiple Cardiac Defects with Interventional Techniques
  44. The Impact of Gestational Age on Resource Utilization After Open Heart Surgery for Congenital Cardiac Disease From Birth to 1 Year of Age
  45. Neurophysiological Effects of Pediatric Balloon Dilatation Procedures
  46. Inhaled Nitric Oxide Therapy in a Critically Ill Neonate with Ebstein's Anomaly
  47. Hypoplastic Left Heart Syndrome: Exploring a Paradigm Shift in Favor of Surgery
  48. Prenatal Detection of Coarctation of the Aorta in a Non-selected Population: A Prospective Analysis of 10 Years of Experience
  49. Femoral Vein Access by Contrast-Guided Puncture in Cardiac Catheterization in Patients Under One Year of Age
  50. Initial Experience With Tadalafil in Pediatric Pulmonary Arterial Hypertension
  51. Balloon Angioplasty for Native Aortic Coarctation in Different Anatomic Variants
  52. Pulmonary Artery Aneurysm in a Child Secondary to Infective Endarteritis
  53. Congenital Complete Atrioventricular Block Associated with QT Prolongation: Description of a Patient with an Unusual Outcome
  54. Incidence of Respiratory Disease During the First Two Years of Life in Children with Hemodynamically Significant Congenital Heart Disease in Italy: A Retrospective Study
  55. Intermediate-Term Results After Extracardiac Conduit Fontan Palliation in Children and Young Adults with Single Ventricle Physiology—A Single-center Experience
  56. Double-Outlet Technique for Tetralogy of Fallot-Type Disease with an Anomalous Coronary Artery
  57. Evaluation of Cardiotoxicity by Tissue Doppler Imaging in Childhood Leukemia Survivors Treated with Low-Dose Anthracycline
  58. Surgical Removal of a Rhabdomyoma in a Neonate as Rescue Therapy
  59. Improved Classification of Coronary Artery Abnormalities Based Only on Coronary Artery z-Scores After Kawasaki Disease
  60. Predicting the Need for Neoaortic Arch Intervention in Infants with Hypoplastic Left Heart Syndrome Through the Glenn Procedure
  61. Lack of Association Between Folate Receptor Autoantibodies and Conotruncal Congenital Heart Defects
  62. Thoracoabdominal Situs: A Practical Approach Accompanied by a Short History of Descriptive Terms
  63. Successful Percutaneous Cardiac Resynchronization Despite an Occlusive Thebesian Valve
  64. Right Aortic Arch, Isolated Left Subclavian Artery and Ductus Arteriosus with Normal Intracardiac Anatomy: Rare Manifestation of Chromosome 22q11 Deletion
  65. A Viable Therapeutic Option: Mechanical Circulatory Support of the Failing Fontan Physiology
  66. Recombinant Factor XIII Reduces Severe Pleural Effusion in Children after Open-Heart Surgery
  67. A Prelude to Fontan
  68. Potential Additional Indicators for Pacemaker Requirement in Isolated Congenital Atrioventricular Block
  69. Stabilizing an Embolized Pre-stent into the Right Ventricle During MELODY Valve Implantation
  70. The Benefit of a General, Systematic Use of Mapping Systems During Electrophysiological Procedures in Children and Teenagers: The Experience of an Adult EP Laboratory
  71. Transient Heart Block in a Neonate Associated with Previously Undiagnosed Maternal Anti-Ro/SSA and Anti-La/SSB Antibodies
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