Authors: Nehad A AbdelLatif Nermien M Sabry Ashraf M Mohamed Mohamed M Abdulla
Publish Date: 2007/05/11
Volume: 138, Issue: 7, Pages: 715-724
Abstract
A series of substituted pyridine pyrazoline and thiopyrimidine derivatives were synthesized from 3acetylpyridine which was prepared from nicotinic acid as a naturally starting material The pharmacological screening showed that many of these compounds have good analgesic and antiparkinsonian activities comparable to Voltarene® and Benzatropine® as reference drugs The structure assignment of the new compounds is based on chemical and spectroscopic evidence The detailed synthesis spectroscopic data and pharmacological properties for synthesized compounds are reported
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