Journal Title
Title of Journal: Monatsh Chem
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Abbravation: Monatshefte für Chemie - Chemical Monthly
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Publisher
Springer Vienna
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Authors: Mokhles M AbdElzaher Samia A Moustafa Ammar A Labib Mamdouh M Ali
Publish Date: 2010/03/27
Volume: 141, Issue: 4, Pages: 387-393
Abstract
A ferrocenyl ligand was prepared from condensation of 11′diacetylferrocene dihydrazone with salicylaldehyde This ligand forms 11 complexes with CoII NiII CuII and ZnII in good yield Characterization of the ligand and complexes was carried out using infrared IR 1H nuclear magnetic resonance NMR electronic absorption and elemental analysis Anticancer activity of the prepared ligand and its complexes against human breast cancer cell line MCF7 was determined and the results were compared with the activity of the commonly used anticancer drug cisplatin Treatments of MCF7 cells with gradually increasing doses 5 10 20 and 40 μg/cm3 of the prepared complexes revealed that the activity of superoxide dismutase and the level of hydrogen peroxide were significantly increased while the activities of catalase and glutathione peroxidase and the levels of reduced glutathione were significantly lowered compared with in MCF7 cells harvested from control The results suggested that the prepared compounds possess significant anticancer activity comparable to the activity of cisplatin and may be potent anticancer agents for inclusion in modern clinical trials
Keywords:
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