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Title of Journal: J Gastrointest Surg

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Abbravation: Journal of Gastrointestinal Surgery

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Springer-Verlag

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DOI

10.1002/hlca.19470300524

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1873-4626

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The Glucagon Provocative Test for the Diagnosis an

Authors: Chikashi Shibata Yuji Funayama Kouhei Fukushima Tatsuya Ueno Atsushi Kohyama Kennichi Satoh Tooru Shimosegawa Tetsuya Yamagiwa Iwao Sasaki
Publish Date: 2007/10/11
Volume: 12, Issue: 2, Pages: 344-349
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Abstract

Three patients with gastrinoma underwent the following examinations 1 preoperative intravenous glucagon test to enable a definitive diagnosis 2 intraarterial glucagon injection test to localize the tumor and 3 intraoperative and postoperative intravenous glucagon test to confirm the completeness of the resectionSerum gastrin levels increased in response to intravenous glucagon in all three patients preoperatively Computed tomography scans revealed a tumor in the lesser omentum pancreatic head and the pancreatic uncinate in cases 1 2 and 3 respectively Intraarterial glucagon test revealed that the feeding artery for the tumor was the left gastric artery in case 1 and the superior mesenteric artery in case 3 Resection of the remnant stomach with tumor pancreaticoduodenectomy with portal vein resection and enucleation of the tumor were performed in cases 1 2 and 3 respectively Serum gastrin levels did not increase in response to intravenous glucagon intraoperatively and postoperatively in cases 1 and 3 Although intravenous glucagon caused a slight increase in serum gastrin in case 2 no recurrent tumors were evident

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