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Title of Journal: J Gastrointest Surg

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Abbravation: Journal of Gastrointestinal Surgery

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Springer US

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1873-4626

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Extracorporeal Hypothermic Perfusion Device for In

Authors: Armando Salim MuñozAbraham Roger PatrónLozano Raja R Narayan Sami S Judeeba Abedalrazaq Alkukhun Tariq I Alfadda Joseph T Belter David C Mulligan Raffaella Morotti Joseph P Zinter John P Geibel Manuel I RodríguezDávalos
Publish Date: 2015/10/20
Volume: 20, Issue: 2, Pages: 313-321
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Abstract

The small intestine is one of the most ischemiasensitive organs used in transplantation To better preserve the intestinal graft viability and decrease ischemiareperfusion injury a device for extracorporeal perfusion was developed We present the results for the first series of perfused human intestine with an intestinal perfusion unit IPUFive human intestines were procured for the protocol 1 An experimental segment was perfused by the IPU delivering cold preservation solution to the vascular and luminal side continually at 4 ºC for 8 h 2 Control jejunum and ileum segments were preserved in static cold preservation Tissue samples were obtained for histopathologic grading according to the Park/Chiu scoring system 0 = normal 8 = transmural infarctionThis data presents proof of concept that extracorporeal intestinal perfusion is feasible The evidence shows that the IPU can preserve the viability of human intestine and histopathologic evaluation of perfused intestine is favorable Our early results can eventually lead to expanding the possibilities of intestinal preservation

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