Authors: Jung Wook Huh Chol Kyoon Cho Hyeong Rok Kim Young Jin Kim
Publish Date: 2010/06/11
Volume: 14, Issue: 8, Pages: 1258-1264
Abstract
A retrospective analysis was performed on 91 consecutive patients with synchronous colorectal liver metastases who underwent resection of the primary colorectal cancer between December 1999 and December 2007 Of the 91 patients 54 593 also underwent complete R0 resection for liver metastases and 84 923 received postoperative chemotherapy The oncologic outcomes and prognostic factors were analyzedOperative mortality was 11 and morbidity was 374 The 3 and 5year overall survival rates were 445 and 268 respectively A multivariate analysis revealed that residual disease after surgery nonR0 resection p = 0003 lymph node metastasis of the primary tumor p = 0015 and no postoperative chemotherapy p = 0001 were independent prognostic factors for poor survival Independent predictors of an inability to achieve a complete resection were the presence of three or more liver metastases and the presence of extrahepatic disease at exploration Significant differences in survival existed among the three risk stratification groups no low and highrisk groups p 0001The inability to safely render the liver and colon microscopically free of disease should cause a surgeon to reconsider synchronous colectomy and hepatectomy A multidisciplinary approach that combines both complete resection of synchronous colorectal liver metastases and postoperative chemotherapy may achieve improved survival in patients with synchronous colorectal liver metastases
Keywords: