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Title of Journal: J Gastrointest Surg

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Abbravation: Journal of Gastrointestinal Surgery

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Springer US

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10.1016/0022-460x(89)91015-8

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1873-4626

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Ezrin Expression Is an Independent Prognostic Fact

Authors: Prabhu Arumugam Stefano Partelli Stacey J Coleman Ivana Cataldo Stefania Beghelli Claudio Bassi Nilukushi Wijesuriya JoAnne Chin Aleong Fieke E M Froeling Aldo Scarpa Hemant M Kocher
Publish Date: 2013/10/24
Volume: 17, Issue: 12, Pages: 2082-2091
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Abstract

Microarrayed pathological tissues of surgically resected colorectal cancer liver metastasis CRLM and whole tissue sections of cancer of the ampulla of Vater CAV were analyzed to determine ezrin expression levels and correlation with survival The requirement of ezrin in invasive capability was assessed using in vitro assaysSurgically resected CAV showing a low ezrin score have a better 5year diseasespecific survival than those showing a high ezrin score P  00001 Similarly high ezrin expression at the invasive front of CRLM resulted in poor diseasefree survival P = 005 Multivariate analysis demonstrated high ezrin expression to be an independent adverse prognostic factor for CAV hazard ratio HR 1522 95  confidence interval CI 198–11703 P  001 and CRLM HR 642 95  CI 101–5243 P = 005 among other clinically relevant variables such as lymph node metastasis for CAV and the presence of extrahepatic disease large hepatic metastases 5 cm and close surgical resection margins 5 mm all for CRLM In vitro experiments indicated that ezrin expression was vital for cellular processes such as adhesive and invasive activityThis work was funded by Cancer Research UK PA European Society of Surgical Oncology International Fellowship SP and NIHR Clinician Scientist Fellowship HMK as well as AIRC Regionale Veneto Associazione Italiana Ricerca sul Cancro Italy the European Community Grant FP7 “EPCTMNET” and Ministero della Salute Rome Italy

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