Authors: Michael J J Chu Anna J Dare Anthony R J Phillips Adam S J R Bartlett
Publish Date: 2015/04/28
Volume: 19, Issue: 9, Pages: 1713-1724
Abstract
There is increasing need to expand availability of donor liver grafts including steatotic livers Steatotic liver is associated with poor outcome posttransplantation but with conflicting results in the literature The aim of this systematic review was to evaluate the impact of steatotic livers on liver transplantation outcomesAn electronic search of OVID Medline and Embase databases was performed to identify clinical studies that reported outcomes of steatotic livers in liver transplantation Data were extracted and basic descriptive statistics were used to summarise data pooled from individual clinical studiesNinetytwo articles were identified of which 34 met the inclusion criteria and stratified analysis were performed There was a lack of standardised definition of primary nonfunction or impaired primary function amongst the studies and description of type of steatosis Severely 60 steatotic grafts are associated with increased risk of poor graft function whilst moderate–severe 30 steatotic grafts are associated with decreased graft survivalAvailable evidence showed increased risk of poor graft outcome in moderate–severe steatotic livers A large prospective multicentred trial will be required to identify the true risks of steatotic livers Consistent definition of primary nonfunction/impaired primary function and description of type of steatosis is also required
Keywords: