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Title of Journal: J Gastrointest Surg

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Abbravation: Journal of Gastrointestinal Surgery

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Springer US

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DOI

10.1002/chin.200615148

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1873-4626

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Immediate Radical Therapy or Conservative Treatmen

Authors: L Jiang J Y Lei W T Wang L N Yan B Li T F Wen M Q Xu J Y Yang Y G Wei
Publish Date: 2014/03/25
Volume: 18, Issue: 6, Pages: 1125-1130
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Abstract

Many advanced hepatocellular carcinoma HCC cases can be successfully downstaged into the Milan criteria however immediate radical therapy cannot be applied to all such patients for various reasons Of the patients who are not eligible for immediate radical therapy some accept repeated downstaging therapies and some undergo persistent observation The aim of the present study was to compare longterm survival between these two groups of patientsBetween August 2003 and October 2008 156 HCC patients successfully received downstaging therapy resulting in compliance with the Milan criteria Of those 98 cases accepted radical therapies including liver transplantation LT resection or radiofrequency ablation RFA group 1 and 58 cases underwent repeated transcatheter arterial chemoembolization TACE or persistent observation group 2 The baseline characteristics demographic data downstaging protocol and information on longterm outcomes were collected and comparedNo significant differences were observed in the patient demographic data downstaging protocols or tumor characteristics between the two groups The 1 3 and 5year overall survival rates were 929 827 and 786  respectively in group 1 whereas these rates were 828 655 and 483  respectively in group 2 P = 0046 Among the 58 patients in group 2 the 1 3 and 5year overall survival rates were 923 654 and 462  respectively in the repeated TACE group and 813 656 and 50  respectively in the persistent observation group P = 0783

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