Paper Search Console

Home Search Page About Contact

Journal Title

Title of Journal: Clin Transl Oncol

Search In Journal Title:

Abbravation: Clinical and Translational Oncology

Search In Journal Abbravation:

Publisher

Springer Milan

Search In Publisher:

DOI

10.1007/s11428-006-0107-x

Search In DOI:

ISSN

1699-3055

Search In ISSN:
Search In Title Of Papers:

Pralatrexate a new hope for aggressive Tcell lym

Authors: Antonio Rueda María Casanova Cristina Quero Ángeles MedinaPérez
Publish Date: 2009/05/06
Volume: 11, Issue: 4, Pages: 215-220
PDF Link

Abstract

Aggressive Tcell lymphomas represent a particularly poorprognosis subgroup of lymphomas This is especially true for patients with recurrent or refractory disease who typically have a limited response to salvage therapy and an extremely poor overall survival There is thus a strong need to develop potentially active drugs for these malignancies Pralatrexate is a novel antifolate designed to have high affinity for the reduced folate carrier type 1 Preclinical and clinical studies have demonstrated that pralatrexate has significant activity against Tcell lymphomas The doselimiting toxicity for pralatrexate is mucositis which could be abrogated with folic acid and vitamin B12 supplementation Pralatrexate is now being evaluated in phase II clinical trials for the treatment of peripheral Tcell lymphoma and in a phase I/II trial in combination with gemcitabine for the treatment of nonHodgkin’s lymphoma Because of the limited therapies available for aggressive Tcell lymphoma pralatrexate could secure a niche for the treatment of this condition provided ongoing clinical trials and future phase III trials confirm the efficacy of the drug


Keywords:

References


.
Search In Abstract Of Papers:
Other Papers In This Journal:

  1. Vesical instillations of hyaluronic acid to reduce the acute vesical toxicity caused by high-dose brachytherapy do not affect the survival: a five-year follow-up study
  2. The expression and function of Frizzled-7 in human renal cell carcinoma
  3. Prognostic significance of preoperative neutrophil/lymphocyte ratio and platelet/lymphocyte ratio in patients with gallbladder carcinoma
  4. Current status of anti-angiogenic agents in the treatment of ovarian carcinoma
  5. Phase II trial of sequential subcutaneous interleukin-2 plus interferon alpha followed by sorafenib in renal cell carcinoma (RCC)
  6. Dose–volume histogram parameters for predicting radiation pneumonitis using receiver operating characteristic curve
  7. Serum C-telopeptide levels predict the incidence of skeletal-related events in cancer patients with secondary bone metastases
  8. Breast metastases from a floor of the mouth carcinoma
  9. Clinical implications of KIT and PDGFRA genotyping in GIST
  10. Therapeutic vaccines for non-Hodgkin B-cell lymphoma
  11. Tissue fatty acid composition and secretory phospholipase-A2 activity in oral squamous cell carcinoma
  12. Prognostic value of circulating tumor cells in metastatic breast cancer: a systemic review and meta-analysis
  13. Gastrointestinal stromal tumours at present: an approach to burning questions
  14. Consensus of the Spanish Society of Radiation Oncology (SEOR) Brachytherapy Group on brachytherapy in Breast Cancer
  15. Sensitive methods for screening of the MEK1 gene mutations in patients with central nervous system metastases of non-small cell lung cancer
  16. Selection of extreme phenotypes: the role of clinical observation in translational research
  17. Multiple bone lesions resembling a metastatic origin. An unexpected diagnosis
  18. VEGFR2 inhibition by RNA interference affects cell proliferation, migration, invasion, and response to radiation in Calu-1 cells
  19. The intra-tumor heterogeneity of cell signaling factors in breast cancer: p4E-BP1 and peIF4E are diffusely expressed and are real potential targets
  20. GAL3ST2 from mammary gland epithelial cells affects differentiation of 3T3-L1 preadipocytes
  21. Helicobacter pylori infection of the larynx may be an emerging risk factor for laryngeal squamous cell carcinoma
  22. Retroperitoneal lymph node dissection: an update in testicular malignancies
  23. Expression and prognostic role of c-Myb as a novel cell cycle protein in esophageal squamous cell carcinoma
  24. Role of axillary ultrasound, magnetic resonance imaging, and ultrasound-guided fine-needle aspiration biopsy in the preoperative triage of breast cancer patients
  25. Role of axillary ultrasound, magnetic resonance imaging, and ultrasound-guided fine-needle aspiration biopsy in the preoperative triage of breast cancer patients

Search Result: