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Title of Journal: Clin Transl Oncol

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Abbravation: Clinical and Translational Oncology

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Springer Milan

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DOI

10.1007/bf01627828

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1699-3055

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The expression and function of Frizzled7 in human

Authors: R Xu S Zeng W Xie C Sun Y L Chen M J Chen L Zhang
Publish Date: 2015/08/05
Volume: 18, Issue: 3, Pages: 269-276
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Abstract

Wnt/βcatenin has emerged as an important signal pathway in renal cell carcinoma RCC pathogenesis Frizzled 7 Fzd7 is a member of Frizzled Fzd receptor family which binds with Wnt ligands and transduces canonical and noncanonical pathways However the expression of Fzd7 in human RCC is poorly investigated53 RCC tissues and peritumor tissues were collected from the patients treated with radical nephrectomy The expression of Fzd7 was investigated by immunohistochemical staining Three RCC cells were transfected with Fzd7shRNA and GFPshRNA to investigate the function of Fzd7 in RCC cellsThe immunohistochemical analysis showed that Fzd7 protein expression level was significantly increased in RCC tissues when compared with peritumor tissues which suggested that Fzd7 might be involved in the formation of tumors However the Fzd7 expression was not correlated with clinicopathological parameters Three RCC cell lines 786O Caki1 and OSRC2 also expressed Fzd7 With Fzd7 expression being interfered by shRNA the RCC cell proliferation was mildly decreased Wnt3a could stimulate the RCC cells proliferation but the stimulation was decreased when Fzd7 expression was interfered Restoring the Fzd7 expression led to the proliferation stimulation effect of Wnt3a being restored

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