Vesical instillations of hyaluronic acid to reduce

Authors: Pilar Ma Samper Ots Concha López Carrizosa Aurora Rodríguez Juan de Dios Sáez José María Delgado Manuel Martín de Miguel Montserrat Vidal

Publish Date: 2009/12/24

Volume: 11, Issue: 12, Pages: 828-

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Abstract

Singlecentre retrospective study of patients diagnosed with cervical and endometrial cancer treated with brachytherapy BT with or without intravesical instillation of HA Patients were assigned consecutively to the two treatment groups Forty milligrams of HA was instilled intravesically for approximately 30 min prior to each BT session Rates of acute and late vesical toxicity were recorded using the RTOG criteriaNinetyfive clinical histories were reviewed 48 with HA instillation and 47 without Surgery had been performed in 853 of cases external radiotherapy in 768 and chemotherapy in 253 There were no significant differences between groups with regard to the total number of BT sessions dose per session total dose or biological equivalent dose In all the sessions the percentage of patients presenting acute vesical toxicity was lower in the HA group the differences being statistically significant p005 after the 2nd 208 vs 404 and 4th sessions 109 vs 319 No patients in the HA group presented vesical toxicity after six months of followup Over the whole study period the percentage of patients presenting vesical toxicity of degree 2 or more was significantly lower in the HA group 208 vs 128 p005

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