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Title of Journal: Clin Transl Oncol

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Abbravation: Clinical and Translational Oncology

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Springer Milan

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DOI

10.1016/0022-1031(81)90015-9

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ISSN

1699-3055

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Tissue fatty acid composition and secretory phosph

Authors: M Askari M Darabi R Zare Mahmudabadi M Oboodiat S Fayezi Z Mostakhdemin Hosseini A Pirzadeh
Publish Date: 2014/10/29
Volume: 17, Issue: 5, Pages: 378-383
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Abstract

Oral squamous cell carcinoma OSCC is a remarkable health problem worldwide but its pathogenesis remains unknown The aim of this study was to compare fat composition and secretory phospholipaseA2 sPLA2 activity between the malignant and adjacent normal squamous tissues in patients with OSCCPaired samples of malignant squamous and adjacent normalappearing tissues were collected from 27 patients with OSCC The fatty acid composition in the obtained tissues was determined by gas liquid chromatography Tissue enzyme activities of sPLA2 were measured using the standard assay with Diheptanoyl ThioPhosphatidylcholine as substrateIn the OSCC tissue the level of stearic acid 180 and activity of sPLA2 were higher P  0001 and the levels of oleic acid 181n9 and linoleic acid 182n6 were lower than that in the adjacent normalappearing squamous tissue P  0001 The activity of sPLA2 in OSCC was strongly negatively correlated with the amount of 182n6 r = −041 P  0001 Negative significant associations were observed between the OSCC invasion and tissue levels of eicosapentaenoic acid EPA and docosahexaenoic acid DHEThis study was supported by the Cancer Research Center Tehran University of Medical Sciences A part of the study was performed as a DMD thesis The authors acknowledge the Dental and Periodontal Research Center at Tabriz University of Medical Sciences The authors would like to thank Masoud Darabi PhD for reading the manuscript and providing helpful suggestions

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