Journal Title
Title of Journal: Clin Transl Oncol
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Abbravation: Clinical and Translational Oncology
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Authors: Hongli Gong Yi Shi Liang Zhou Lei Tao Yong Shi Wenjun Cao Lei Cheng
Publish Date: 2012/07/24
Volume: 14, Issue: 12, Pages: 905-910
Abstract
Several studies have implicated Helicobacter pylori as a risk factor in laryngeal cancer but other studies disagree It is fundamental that the relationship between Helicobacter pylori and laryngeal cancer be verified in order to provide evidence of ways to prevent the initiation and development of this carcinomaIn total 81 patients with laryngeal squamous cell carcinoma and 75 control subjects were enrolled in a case–control study Seminested polymerase chain reaction techniques were applied to detect Helicobacter pylori in the laryngeal mucosa and enzymelinked immunosorbent assays were used to detect serum antibodies against Helicobacter pylori Risk factors associated with laryngeal carcinoma were analyzed using logistic regression modelsThe presence of Helicobacter pylori in the larynx was higher in patients with laryngeal cancer than in control subjects 716 vs 253 p 0001 Among patients with laryngeal carcinoma rates of Helicobacter pylori infection were higher in normal laryngeal tissues than in tumor tissues After adjusting for confounding factors regression analysis indicated that the microbe was an independent risk factor for laryngeal cancer OR = 715 95 CI 329 1553 p 0001This study suggests that Helicobacter pylori is present in the mucosa of the larynx The microorganism may be an independent risk factor for laryngeal squamous cell carcinoma The laryngeal mucosa thus provides a reservoir for the bacteria possibly and is a likely staging place for its transmission to other areas
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