Prognostic significance of preoperative neutrophil

Authors: Y Zhang C Jiang J Li J Sun X Qu

Publish Date: 2015/06/16

Volume: 17, Issue: 10, Pages: 810-818

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Abstract

Neutrophil/lymphocyte ratio NLR and platelet/lymphocyte ratio PLR were immune responserelated indicators Preoperative NLR and PLR had been considered to be related to the prognosis of various cancers The objective of this study was to evaluate the prognostic significance of NLR and PLR in patients with gallbladder carcinoma GBCFrom 2001 to 2013 145 patients with GBC were recruited in this retrospective study Cutoff values of NLR and PLR were determined by receiver operating characteristic curves ROC The correlation of clinical data including tumor differentiation nevin stage TNM stage operation margin operation mode NLR PLR hemoglobin C reactive protein CRP carcinoembryonic antigen CEA and carbohydrate antigen 199 CA199 with median survival period of patients was analyzed by univariate survival analysis The multivariate prognosis analysis was performed to select the independent prognostic factorsThe cutoff values of NLR and PLR were 194 and 11334 respectively Compared with low NLR and low PLR group the 5year survival rates in high NLR and high PLR group were reduced P  005 The degree of tumor differentiation nevin stage TNM stage operation mode NLR PLR CA199 total bilirubin CRP and CEA were associated with the median survival period of patients P  001 The multivariate prognosis analysis showed that NLR nevin stage operation mode and hemoglobin were independent prognostic factors P  005

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