Prognostic value of circulating tumor cells in met

Authors: Q Lv L Gong T Zhang J Ye L Chai C Ni Y Mao

Publish Date: 2015/08/11

Volume: 18, Issue: 3, Pages: 322-330

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Abstract

Metastatic breast cancer MBC remains the main cause of cancerrelated death and the clinical significance and prognostic role of circulating tumor cells CTCs in metastatic breast cancer are still controversial Here we conducted a metaanalysis to clarify the correlation between CTCs and the clinicopathological features and prognosis of MBCWe performed a comprehensive search of Pubmed and the ISI Web of Science through December 2014 Only articles that focused on MBC patients and detected CTCs using the CellSearch system were included The associations between CTCs and survival rate and clinicopathological parameters including molecular pattern metastatic region and treatment response were evaluatedThis metaanalysis included 24 studies 3701 MBC patients 13 prospective studies and 11 retrospective studies We found that CTCs were more frequently detected with HER2 + primary tumors pooled RR = 073 95  CI = 063–084 Additionally higher CTC numbers indicated a worse treatment response RR = 056 95  CI = 040–079 poorer PFS RR = 064 95  CI = 056–073 and poorer OS RR = 069 95  CI = 064–075 in MBC patientsBased on these results we propose that HER2 positivity could be a significant risk factor for the presence of CTCs Additionally CTCs have a significant prognostic value for MBC patients Therefore CTCs should be continually monitored to guide the treatment of MBC patients especially those with HER2 + primary tumorsThis work was supported by the Science and Technology Department of Zhejiang Province Grant numbers Y15H160158 Q15H070012 LY12H13002 Science and Technology Department of Ningbo Grant number 2012A610205 Healthy and Scientific Project of Zhejiang Province Grant number 2015RCB026

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