Authors: Urs D A MüllerRichter Albert Dowejko Silvia Peters Stephan Rauthe Tobias Reuther Stefan Gattenlöhner Torsten E Reichert Oliver Driemel Alexander C Kübler
Publish Date: 2009/06/02
Volume: 14, Issue: 3, Pages: 291-296
Abstract
MAGEA antigens are only expressed on tumor cells The aim of this study was to identify their expression in patients with oral squamous cell carcinoma OSCC Fortyseven patients with primary OSCC was selected retrospectively Histopathological sections were stained immunohistochemically with MAGEA antibody 57B The results were evaluated regarding tumor size T lymphnode metastasis N blood vessel infiltration V lymph vessel infiltration L grading G and sex MAGEA antigens were expressed in 55 of all patients Expression increased with tumor size T1 = 56 T2 = 44 T3 = 67 T4 = 71 Lymphnode metastasis had no influence N0 and N1 about 50 Tumors with blood and lymph vessel infiltration had higher expression V0 = 50 V1 = 100 L0 = 46 L1 = 71 Lessdifferentiated tumors showed higher rates G1 = 50 G2 = 45 G3 = 83 OSCC in men were positive in 62 and in women in 38 MAGEA antigens are frequently expressed in OSCC Their expression seems to increase with tumor dedifferentiation
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