Authors: Ann Bröchner Carsten Christensen Bjarne Kristensen Sofia Tranæus Lena Karlsson Liselotte Sonnesen Svante Twetman
Publish Date: 2010/04/10
Volume: 15, Issue: 3, Pages: 369-373
Abstract
This study aims to investigate the effect of topical applications of 10 casein phosphopeptide–amorphous calcium phosphate CPP–ACP on white spot lesions WSL detected after treatment with fixed orthodontic appliances Sixty healthy adolescents with ≥1 clinically visible WSL at debonding were recruited and randomly allocated to a randomised controlled trial with two parallel groups The intervention group was instructed to topically apply a CPP–ACP containing agent Tooth Mousse GC Europe once daily and the subjects of the control group brushed their teeth with standard fluoride toothpaste The intervention period was 4 weeks and the endpoints were quantitative lightinduced fluorescence QLF on buccal surfaces of the upper incisors cuspids and first premolars and visual scoring from digital photos The attrition rate was 15 mostly due to technical errors and 327 lesions were included in the final evaluation A statistically significant p 005 regression of the WSL was disclosed in both study groups compared to baseline but there was no difference between the groups The mean area of the lesions decreased by 58 in the CPP–ACP group and 26 in the fluoride group p = 006 The QLF findings were largely reflected by the clinical scores No side effects were reported Topical treatment of white spot lesions after debonding of orthodontic appliances with a casein phosphopeptidestabilised amorphous calcium phosphate agent resulted in significantly reduced fluorescence and a reduced area of the lesions after 4 weeks as assessed by QLF The improvement was however not superior to the “natural” regression following daily use of fluoride toothpaste
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