Authors: Rashi Chaturvedi Mili Gupta Ashish Jain Tarun Das Savita Prashar
Publish Date: 2014/03/05
Volume: 19, Issue: 1, Pages: 45-52
Abstract
Periodontitis involves a complex interplay of microorganisms and host immune response via numerous mediator molecules playing strategic roles in its pathogenesis Soluble CD40L sCD40L is one such costimulatory molecule which is essential for Thelper cell activation and is a wellknown risk indicator of cardiovascular diseases The levels of this marker in crevicular fluid of patients of chronic periodontitis have been explored in the present study for the first time along with an analysis of its association with levels in serum in otherwise systemically healthy patientsSixty patients 20 healthy and 40 of chronic periodontitis 18 moderate and 22 severe participated in the study Patients of the diseased group underwent nonsurgical periodontal therapy Clinical evaluation and collection of gingival crevicular fluid GCF and serum samples was done at baseline and 6 weeks after phase I periodontal therapy sCD40L levels were quantified in the fluids using ELISALevels of sCD40L in GCF were significantly higher in the diseased group p ≤ 0001 and strongly correlated not only with increasing severity of disease but also with levels in serum In posttreatment the levels decreased significantly in both the biological fluids p ≤ 0001
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