Authors: Luciano Tavares Angelo Cintra Renata Oliveira Samuel Mariane Maffei Azuma Clícia Pereira Ribeiro Luis Gustavo Narciso Valéria Marçal Felix de Lima Dóris Hissako Sumida Gilberto Aparecido Coclete Eloi DezanJúnior João Eduardo GomesFilho
Publish Date: 2014/01/25
Volume: 18, Issue: 9, Pages: 2123-2128
Abstract
Eighty male Wistar rats were divided into eight groups of ten animals each normoglycemic AP PD AP+PD DM DM+AP DM+PD and DM+AP+PD DM was induced using streptozotocin AP by dental pulp exposure to the oral environment and PD by periodontal ligature The animals were sacrificed after 30 days and venous blood samples were collected via cardiac puncture to determine the serum IL17 and neutrophil levels The maxillae were dissected and processed for radiographic analysis The periapical lesion areas were quantified in pixels The total assessed values were tabulated according to each experimental group and were statistically analyzed using Spearman’s correlation and KruskalWallis test p 005A significant difference in the serum IL17 levels was observed between the groups without oral infections and the groups with AP+PDassociated lesions regardless of the presence of DM p 005 Diabetes increased the neutrophil levels regardless of the presence of oral infection However a combination of two oral infections increased the neutrophil levels in DM rats p 005 The level of bone resorption lesions was greater in DM rats than in normoglycemic rats p 005
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