Microbiological profile and calprotectin expressio

Authors: Roberto Farina Maria Elena Guarnelli Elena Figuero David Herrera Mariano Sanz Leonardo Trombelli

Publish Date: 2011/11/30

Volume: 16, Issue: 5, Pages: 1475-1484

PDF Link

Abstract

Thirtyseven periodontally healthy subjects were evaluated in real life conditions NO gingivitis as well as after 21 days of experimental gingivitis trial EI gingivitis During the experimental gingivitis trial in one maxillary quadrant test quadrant gingival inflammation was induced by oral hygiene abstention while in the contralateral control quadrant oral hygiene was routinely continuedThe results of the study showed that 1 the microbiological profile of quadrants where gingival inflammation was experimentally induced ie EI test quadrants differed significantly from that of either quadrants where gingival inflammation was controlled by proper plaque control ie EI control quadrants or quadrants with NO gingivitis and 2 GCF calprotectin was significantly higher at EI test quadrants compared to either EI control quadrants or quadrants with NO gingivitis A positive intrasubject correlation was found between GCF concentration of calprotectin at sites presenting NO and EI gingivitisNO and EI gingivitis showed a different microbiological profile of the subgingival environment GCF calprotectin is a reliable marker of gingival inflammation and its concentration in NO gingivitis is correlated with its expression in EI gingivitisThe modality of plaque accumulation seems to affect the subgingival microbiological profile associated with a gingivitis condition Calprotectin levels in GCF may be regarded as a promising marker of the individual susceptibility to develop gingival inflammation in response to experimentally induced plaque accumulationThe present study was supported by the Research Centre for the Study of Periodontal and PeriImplant Diseases University of Ferrara Italy and by GABA International Therwil Switzerland We are grateful to Drs Marina Tosi Elisa Orlandini and Sabrina Bottega from the University of Ferrara for their clinical service

Keywords: