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Title of Journal: J Ind Microbiol Biotechnol

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Abbravation: Journal of Industrial Microbiology & Biotechnology

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Springer-Verlag

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DOI

10.1016/0010-7824(91)90040-m

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1476-5535

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Enhancement of extracellular purine nucleoside acc

Authors: Anastasia S Sheremet Sergey V Gronskiy Ravil A Akhmadyshin Anna E Novikova Vitaliy A Livshits Rustem S Shakulov Natalia P Zakataeva
Publish Date: 2010/09/03
Volume: 38, Issue: 1, Pages: 65-70
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Abstract

Using a simple method to introduce genetic modifications into the chromosome of naturally nontransformable Bacillus a set of markerfree inosineproducing and 5aminoimidazole4carboxamide AICA ribonucleosideproducing Bacillus amyloliquefaciens strains has been constructed These strains differ in expression levels of the genes responsible for nucleoside export Overexpression of B amyloliquefaciens pbuE and heterologous expression of Escherichia coli nepI which encode nucleoside efflux transporters each notably enhanced inosine production by a B amyloliquefaciens nucleosideproducing strain pbuE overexpression was found to increase AICA ribonucleoside accumulation indicating that the substrate specificity of the PbuE pump extends to this nucleoside These results demonstrate that identifying genes whose products facilitate transport of a desired nucleoside out of cells and enhancing their expression can improve the performance of strains used for industrial production

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  2. Wood pulp as an immobilization matrix for the continuous production of isopropanol and butanol
  3. Persistence of Methanosaeta populations in anaerobic digestion during process instability
  4. Xylitol production from DEO hydrolysate of corn stover by Pichia stipitis YS-30
  5. Biorefining of wood: combined production of ethanol and xylanase from waste fiber sludge
  6. Do we need new antibiotics? The search for new targets and new compounds
  7. Sporicidal efficacy of pH-adjusted bleach for control of bioburden on production facility surfaces
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  9. Engineered glucose isomerase from Streptomyces sp. SK is resistant to Ca 2+ inhibition and Co 2+ independent
  10. Universal species concept: pipe dream or a step toward unifying biology?
  11. A strategy to prevent the occurrence of Lactobacillus strains using lactate-tolerant yeast Candida glabrata in bioethanol production
  12. Recent biotechnological progress in enzymatic synthesis of glycosides
  13. Enhanced production of poly(3-hydroxybutyrate- co -4-hydroxybutyrate) copolymer with manipulated variables and its properties
  14. Comparison of the secondary metabolites in two scales of cephalosporin C (CPC) fermentation and two different post-treatment processes
  15. Clostridium beijerinckii mutant with high inhibitor tolerance obtained by low-energy ion implantation
  16. Enhanced production of CoQ 10 by newly isolated Sphingomonas sp. ZUTEO3 with a coupled fermentation–extraction process
  17. Enhanced production of CoQ 10 by newly isolated Sphingomonas sp. ZUTEO3 with a coupled fermentation–extraction process
  18. Ivan Málek and the Institute of Microbiology
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  20. A whole cell biocatalyst for double oxidation of cyclooctane
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  22. A multi-factors rational design strategy for enhancing the thermostability of Escherichia coli AppA phytase
  23. Use of interdelta polymorphisms of Saccharomyces cerevisiae strains to monitor population evolution during wine fermentation
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  28. Fungal β-glucosidase expression in Saccharomyces cerevisiae
  29. Development of a biochip using antibody-coated gold nanoparticles to detect specific bioparticles
  30. Significance of oxygen carriers and role of liquid paraffin in improving validamycin A production
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