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Title of Journal: J Ind Microbiol Biotechnol

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Abbravation: Journal of Industrial Microbiology & Biotechnology

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Springer-Verlag

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DOI

10.1002/3527601724.fmatter

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1476-5535

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Do we need new antibiotics The search for new tar

Authors: Jaroslav Spížek Jitka Novotná Tomáš Řezanka Arnold L Demain
Publish Date: 2010/11/18
Volume: 37, Issue: 12, Pages: 1241-1248
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Abstract

Resistance to antibiotics and other antimicrobial compounds continues to increase There are several possibilities for protection against pathogenic microorganisms for instance preparation of new vaccines against resistant bacterial strains use of specific bacteriophages and searching for new antibiotics The antibiotic search includes 1 looking for new antibiotics from nontraditional or less traditional sources 2 sequencing microbial genomes with the aim of finding genes specifying biosynthesis of antibiotics 3 analyzing DNA from the environment metagenomics 4 reexamining forgotten natural compounds and products of their transformations and 5 investigating new antibiotic targets in pathogenic bacteria

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Other Papers In This Journal:
  1. Production of a novel extracellular acidic lipase from Pseudomonas gessardii using slaughterhouse waste as a substrate
  2. Wood pulp as an immobilization matrix for the continuous production of isopropanol and butanol
  3. Persistence of Methanosaeta populations in anaerobic digestion during process instability
  4. Xylitol production from DEO hydrolysate of corn stover by Pichia stipitis YS-30
  5. Biorefining of wood: combined production of ethanol and xylanase from waste fiber sludge
  6. Sporicidal efficacy of pH-adjusted bleach for control of bioburden on production facility surfaces
  7. A novel methodology independent of fermentation rate for assessment of the fructophilic character of wine yeast strains
  8. Engineered glucose isomerase from Streptomyces sp. SK is resistant to Ca 2+ inhibition and Co 2+ independent
  9. Universal species concept: pipe dream or a step toward unifying biology?
  10. A strategy to prevent the occurrence of Lactobacillus strains using lactate-tolerant yeast Candida glabrata in bioethanol production
  11. Recent biotechnological progress in enzymatic synthesis of glycosides
  12. Enhanced production of poly(3-hydroxybutyrate- co -4-hydroxybutyrate) copolymer with manipulated variables and its properties
  13. Comparison of the secondary metabolites in two scales of cephalosporin C (CPC) fermentation and two different post-treatment processes
  14. Clostridium beijerinckii mutant with high inhibitor tolerance obtained by low-energy ion implantation
  15. Enhanced production of CoQ 10 by newly isolated Sphingomonas sp. ZUTEO3 with a coupled fermentation–extraction process
  16. Enhanced production of CoQ 10 by newly isolated Sphingomonas sp. ZUTEO3 with a coupled fermentation–extraction process
  17. Ivan Málek and the Institute of Microbiology
  18. Polyhydroxyalkanoate biosynthesis and simultaneous remotion of organic inhibitors from sugarcane bagasse hydrolysate by Burkholderia sp.
  19. A whole cell biocatalyst for double oxidation of cyclooctane
  20. SlnM gene overexpression with different promoters on natamycin production in Streptomyces lydicus A02
  21. A multi-factors rational design strategy for enhancing the thermostability of Escherichia coli AppA phytase
  22. Use of interdelta polymorphisms of Saccharomyces cerevisiae strains to monitor population evolution during wine fermentation
  23. Antimicrobial susceptibility of Lactobacillus species isolated from commercial ethanol plants
  24. Distribution of live and dead cells in pellets of an actinomycete Amycolatopsis balhimycina and its correlation with balhimycin productivity
  25. Enhanced 1,3-propanediol production by supply of organic acids and repeated fed-batch culture
  26. Enhancement of extracellular purine nucleoside accumulation by Bacillus strains through genetic modifications of genes involved in nucleoside export
  27. Increasing succinic acid production using the PTS-independent glucose transport system in a Corynebacterium glutamicum PTS-defective mutant
  28. Fungal β-glucosidase expression in Saccharomyces cerevisiae
  29. Development of a biochip using antibody-coated gold nanoparticles to detect specific bioparticles
  30. Significance of oxygen carriers and role of liquid paraffin in improving validamycin A production
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