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Title of Journal: J Ind Microbiol Biotechnol

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Abbravation: Journal of Industrial Microbiology & Biotechnology

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Springer-Verlag

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DOI

10.1007/bf00682752

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ISSN

1476-5535

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Comparison of the secondary metabolites in two sca

Authors: YingXiu Cao Hua Lu Bin Qiao Yao Chen YingJin Yuan
Publish Date: 2012/10/09
Volume: 40, Issue: 1, Pages: 95-103
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Abstract

Cephalosporin C CPC is the precursor of a class of antibiotics that were more effective than traditional penicillins CPC production is performed mainly through fermentation by Acremonium chrysogenum whose secondary metabolism was sensitive to the environmental changes In the present work secondary metabolites were measured by ionpair reversedphase liquid chromatography tandemed with hybrid quadrupole timeofflight mass spectrometry and the disparity of them from two scales of CPC fermentations pilot and industrial and also two different posttreatment processes oxalic acid and formaldehyde added and control were investigated When fermentation size was enlarged from pilot scale 50 l to industrial scale 156000 l the remarkable disparities of concentrations and changing trends of the secondary metabolites in A chrysogenum were observed which indicated that the productivity of CPC biosynthesis was higher in the large scale of fermentation Three environmental factors were measured and the potential reasons that might cause the differences were analyzed In the posttreatment process after industrial fermentation the changes of these secondary metabolites in the tank where oxalic acid and formaldehyde were added were much less than the control tank where none was added This indicated that the quality of the final product was more stable after the oxalic acid and formaldehyde were added in the posttreatment process These findings provided new insight into industrial CPC productionThe authors are grateful for the financial support from the National Hightech RD Program 863 Program 2012AA021204 2012AA02A701 National Basic Research Program of China 973 Program 2013CB733601 and the National Natural Science Foundation of China Major International Joint Research Project 21020102040


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  2. Wood pulp as an immobilization matrix for the continuous production of isopropanol and butanol
  3. Persistence of Methanosaeta populations in anaerobic digestion during process instability
  4. Xylitol production from DEO hydrolysate of corn stover by Pichia stipitis YS-30
  5. Biorefining of wood: combined production of ethanol and xylanase from waste fiber sludge
  6. Do we need new antibiotics? The search for new targets and new compounds
  7. Sporicidal efficacy of pH-adjusted bleach for control of bioburden on production facility surfaces
  8. A novel methodology independent of fermentation rate for assessment of the fructophilic character of wine yeast strains
  9. Engineered glucose isomerase from Streptomyces sp. SK is resistant to Ca 2+ inhibition and Co 2+ independent
  10. Universal species concept: pipe dream or a step toward unifying biology?
  11. A strategy to prevent the occurrence of Lactobacillus strains using lactate-tolerant yeast Candida glabrata in bioethanol production
  12. Recent biotechnological progress in enzymatic synthesis of glycosides
  13. Enhanced production of poly(3-hydroxybutyrate- co -4-hydroxybutyrate) copolymer with manipulated variables and its properties
  14. Clostridium beijerinckii mutant with high inhibitor tolerance obtained by low-energy ion implantation
  15. Enhanced production of CoQ 10 by newly isolated Sphingomonas sp. ZUTEO3 with a coupled fermentation–extraction process
  16. Enhanced production of CoQ 10 by newly isolated Sphingomonas sp. ZUTEO3 with a coupled fermentation–extraction process
  17. Ivan Málek and the Institute of Microbiology
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  19. A whole cell biocatalyst for double oxidation of cyclooctane
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  21. A multi-factors rational design strategy for enhancing the thermostability of Escherichia coli AppA phytase
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  23. Antimicrobial susceptibility of Lactobacillus species isolated from commercial ethanol plants
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  26. Enhancement of extracellular purine nucleoside accumulation by Bacillus strains through genetic modifications of genes involved in nucleoside export
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  28. Fungal β-glucosidase expression in Saccharomyces cerevisiae
  29. Development of a biochip using antibody-coated gold nanoparticles to detect specific bioparticles
  30. Significance of oxygen carriers and role of liquid paraffin in improving validamycin A production

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