Journal Title
Title of Journal: Arch Toxicol
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Abbravation: Archives of Toxicology
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Publisher
Springer-Verlag
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Authors: Alfredo Santovito Piero Cervella Massimiliano Delpero
Publish Date: 2010/10/12
Volume: 85, Issue: 6, Pages: 689-693
Abstract
Thiabendazole is a benzimidazolederived compound widely employed in agriculture as anthelmintic and fungicide It is also used as a postharvest fungicide for imported citrus fruits during transport and storage and thus it was found at high concentration in fruits and vegetables Several studies have analyzed the potential genotoxic effect of thiabendazole on different prokaryotic and eukaryotic systems but in many cases results were contradictory In the present study the genotoxic potential of thiabendazole have been evaluated by micronucleus assay in freshly isolated human peripheral lymphocytes The cells were incubated with 05 5 and 50 μg/ml concentrations of the tested substance for 48 h at 37°C Mitomycin C at final concentration of 001 μg/ml culture was used as a positive control The results indicated that the thiabendazole significantly P 005 increased the micronucleus frequency compared with the negative control in all treatment concentrations indicating a potential aneugenic hazard of thiabendazole in cultured human peripheral lymphocytes The cytokinesisblock proliferation index value however was not decreased significantly compared with the negative control Significant P 005 differences in the micronuclei frequency were also found between the lower dose 05 μg/ml and the other two analyzed doses of thiabendazole In contrast no differences were found between 5 and 50 μg/ml of thiabendazole and between DMSO and negative control Finally control cultures treated with the known mutagen MMC showed a very consistent increase in MN with respect to the negative controls
Keywords:
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