Authors: Xiaochen Zhang Wen Li Zhuo Yang
Publish Date: 2015/09/21
Volume: 89, Issue: 12, Pages: 2207-2217
Abstract
Nanosized titanium dioxide nanoTiO2 has tremendous potential for a host of applications and TiO2 nanoparticles NP possess different physicochemical properties compared to their fine particle analogs which might alter their bioactivity Their adverse effects on living cells have raised serious concerns recently for their use in health care and consumer sectors such as sunscreens cosmetics pharmaceutical additives and implanted biomaterials Many researches have demonstrated that the physicochemical properties including shape size surface characteristics and inner structure of nanoTiO2 particles have different degrees of toxicity to different organism groups under different conditions Some former reports have demonstrated that nanoTiO2 materials could enter into human body through different routes such as inhalation dermal penetration and ingestion After being taken by human body NP might induce oxidative stress cytotoxicity genotoxicity inflammation and cell apoptosis ultimately in mammal organs and systems Here we summarized the update about toxicity of nanoTiO2 and aimed to supply a safety usage guideline of this nanomaterial
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