Journal Title
Title of Journal: Arch Toxicol
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Abbravation: Archives of Toxicology
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Publisher
Springer-Verlag
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Authors: Yalçın Duydu Nurşen Başaran Aylin Üstündağ Sevtap Aydın Ülkü Ündeğer Osman Yavuz Ataman Kaan Aydos Yalçın Düker Katja Ickstadt Britta Schulze Waltrup Klaus Golka Hermann M Bolt
Publish Date: 2011/08/11
Volume: 86, Issue: 1, Pages: 27-35
Abstract
An extension of a male reproductive study conducted in a boric acid/borate production zone at Bandırma Turkey is presented The relation between DNAstrand breaks COMET assay neutral and alkaline version in sperm cells and previously described sperm quality parameters was investigated in boronexposed males A correlation between blood boron levels and mean DNAstrand breaks in sperm was weak and DNAstrand breaks in sperm were statistically not different between control and exposed groups Therefore increasing boron exposures had no additional contribution in addition to already preexisting DNAstrand breaks in the sperm cells Weak but statistically significant correlations between DNAstrand breaks and motility/morphology parameters of sperm samples were observed in the neutral version of the COMET assay while correlations between the same variables were statistically not significant in the alkaline version A likely reason for these negative results even in highly exposed humans is that experimental exposures that had led to reproductive toxicity in animals were significantly higher than any boron exposures which may be reached under realistic human conditionsThe project was supported by the National Boron Research Institute BOREN and by the Eti Mine Works General Management 2008G0207 The outline of the study and the processing of the raw data were reviewed by an external expert panel The authors thank the reviewers Professors G Assennato Bari and M Guillemin Lausanne for their scrutiny and dedicated effort
Keywords:
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