Paper Search Console

Home Search Page About Contact

Journal Title

Title of Journal: Arch Toxicol

Search In Journal Title:

Abbravation: Archives of Toxicology

Search In Journal Abbravation:

Publisher

Springer Berlin Heidelberg

Search In Publisher:

DOI

10.1016/0160-4120(87)90032-8

Search In DOI:

ISSN

1432-0738

Search In ISSN:
Search In Title Of Papers:

Mechanisms of amiodarone and valproic acid induced

Authors: Alexa P Vitins Anne S Kienhuis Ewoud N Speksnijder Marianne Roodbergen Mirjam Luijten Leo T M van der Ven
Publish Date: 2014/02/18
Volume: 88, Issue: 8, Pages: 1573-1588
PDF Link

Abstract

Liver injury is the leading cause of druginduced toxicity For the evaluation of a chemical compound to induce toxicity in this case steatosis or fatty liver it is imperative to identify markers reflective of mechanisms and processes induced upon exposure as these will be the earliest changes reflective of disease Therefore an in vivo mouse toxicogenomics study was completed to identify common pathways nuclear receptor NR binding sites and genes regulated by three known human steatosisinducing compounds amiodarone AMD valproic acid VPA and tetracycline TET Over 1 4 and 11 days of treatment AMD induced changes in clinical chemistry parameters and histopathology consistent with steatosis Common processes and NR binding sites involved in lipid retinol and drug metabolism were found for AMD and VPA but not for TET which showed no response Interestingly the pattern of enrichment of these common pathways and NR binding sites over time was unique to each compound Eleven biomarkers of steatosis were identified as dose responsive and time sensitive to toxicity for AMD and VPA Finally this in vivo mouse study was compared to an AMD rat in vivo an AMD mouse primary hepatocyte and a VPA human primary hepatocyte study to identify concordance for steatosis We conclude that concordance is found on the process level independent of species model or dosetime pointThe authors wish to thank Dr EH Jansen PK Beekhof and J Robinson for performing clinical chemistry and histotechnology procedures and Dr I Tonk for help in the dose response analysis This work was supported by the Netherlands Genomics Initiative/Netherlands Organization for Scientific Research NWO no 05006510


Keywords:

References


.
Search In Abstract Of Papers:
Other Papers In This Journal:

  1. Knockout of arsenic (+3 oxidation state) methyltransferase results in sex-dependent changes in phosphatidylcholine metabolism in mice
  2. Effects of nano particles on cytokine expression in murine lung in the absence or presence of allergen
  3. Cisplatin-induced nephrotoxicity is associated with oxidative stress, redox state unbalance, impairment of energetic metabolism and apoptosis in rat kidney mitochondria
  4. Assessment of DNA integrity (COMET assay) in sperm cells of boron-exposed workers
  5. In vitro aneugenic effects of the fungicide thiabendazole evaluated in human lymphocytes by the micronucleus assay
  6. Size influences the cytotoxicity of poly (lactic-co-glycolic acid) (PLGA) and titanium dioxide (TiO 2 ) nanoparticles
  7. Hexabromocyclododecane facilitates FSH activation of ERK1/2 and AKT through epidermal growth factor receptor in rat granulosa cells
  8. Potential impact of ABCB1 (p-glycoprotein) polymorphisms on avermectin toxicity in humans
  9. Comet assay: an essential tool in toxicological research
  10. Acute liver effects, disposition and metabolic fate of [ 14 C]-fenclozic acid following oral administration to normal and bile-cannulated male C57BL/6J mice
  11. Alternative methods to safety studies in experimental animals
  12. Retrospective analysis of the Draize test for serious eye damage/eye irritation: importance of understanding the in vivo endpoints under UN GHS/EU CLP for the development and evaluation of in vitro test methods
  13. Acknowledgement to referees
  14. Impact of a synthetic cannabinoid (CP-47,497-C8) on protein expression in human cells: evidence for induction of inflammation and DNA damage
  15. Embryonic exposure to lead: comparison of immune and cellular responses in unchallenged and virally stressed chickens
  16. Tissue concentrations and induction of a hepatic monooxygenase in male Wistar rats after repeated doses of defined polychlorinated dibenzo- p -dioxin and dibenzofuran (PCDDs and PCDFs) mixtures
  17. Hepatotoxicity by combination treatment of temozolomide, artesunate and Chinese herbs in a glioblastoma multiforme patient: case report review of the literature
  18. Dose–response relationship of temozolomide, determined by the Pig-a , comet, and micronucleus assay
  19. How much nicotine kills a human? Tracing back the generally accepted lethal dose to dubious self-experiments in the nineteenth century
  20. Myosin heavy chain expression pattern as a marker for anabolic potency: desoxymethyltestosterone (madol), norandrostendione and testosterone repress MHC-IIb expression and stimulate MHC-IId/x expression in orchiectomized rat gastrocnemius muscle
  21. Ceramide/sphingomyelin cycle involvement in gentamicin-induced cochlear hair cell death
  22. Use of two validated in vitro tests to assess the embryotoxic potential of mycophenolic acid
  23. Highlight report: quality control for genome-wide expression data: how to identify sample mix-up
  24. Highlight report: perspectives in stem cell research—unbiased quantification of the similarity between in vitro generated and primary hepatocytes
  25. Overlooking relevant confounders in the assessment of pesticides and human health: a reply to Mostafalou and Abdollahi
  26. Uterotrophic assay, Hershberger assay, and subacute oral toxicity study of 4,4′-butylidenebis(2- tert -butyl-5-methylphenol) and 3-(dibutylamino)phenol, based on the OECD draft protocols
  27. Propofol reduces nitric oxide biosynthesis in lipopolysaccharide-activated macrophages by downregulating the expression of inducible nitric oxide synthase
  28. Quantification of individual glutathione S -transferase isozymes in hepatic and pulmonary tissues of naphthalene-tolerant mice
  29. Toxicology of nanosized titanium dioxide: an update
  30. Butyrate alters expression of cytochrome P450 1A1 and metabolism of benzo[ a ]pyrene via its histone deacetylase activity in colon epithelial cell models
  31. Modulation of urinary polycyclic aromatic hydrocarbon metabolites by enzyme polymorphisms in workers of the German Human Bitumen Study
  32. IGF-1 prevents simvastatin-induced myotoxicity in C2C12 myotubes
  33. Induction of peroxisome proliferator-activated receptor alpha (PPARα)-related enzymes by di(2-ethylhexyl) phthalate (DEHP) treatment in mice and rats, but not marmosets

Search Result: