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Title of Journal: Arch Toxicol

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Abbravation: Archives of Toxicology

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Springer Berlin Heidelberg

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DOI

10.1016/0017-9310(96)00015-4

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1432-0738

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Knockout of arsenic +3 oxidation state methyltra

Authors: Madelyn C Huang Christelle C Douillet Miroslav Stýblo
Publish Date: 2016/09/03
Volume: 90, Issue: 12, Pages: 3125-3128
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Abstract

Arsenic +3 oxidation state methyltransferase is the key enzyme in the methylation pathway for inorganic arsenic We have recently shown that As3mt knockout KO has a profound effect on metabolomic profiles in mice Phosphatidylcholine species PCs were the largest group of metabolites altered in both plasma and urine The present study used targeted analysis to investigate the KOassociated changes in PC profiles in the liver the site of PC synthesis Results show that As3mt KO has a systemic effect on PC metabolism and that this effect is sex dependent

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