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Title of Journal: Fish Physiol Biochem

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Abbravation: Fish Physiology and Biochemistry

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Springer Netherlands

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DOI

10.1016/0882-4010(91)90067-K

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ISSN

1573-5168

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Unmethylated CpG oligodeoxynucleotides activate he

Authors: Christopher Marlowe A Caipang Sanchala Gallage Carlo C Lazado Monica F Brinchmann Viswanath Kiron
Publish Date: 2010/03/28
Volume: 36, Issue: 4, Pages: 1151-1158
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Abstract

Bacterial DNA and synthetic oligodeoxynucleotides ODNs that contain unmethylated CpG motifs are strong inducers of immune response in most mammalian organisms The use of these synthetic CpG motifs in fish particularly in salmonids and carp resulted in the modulation of their immune system However much less is known in other species of fish such as gadoids including Atlantic cod Gadus morhua Using head kidney HK leukocytes of cod in an in vitro study we determined the effects of some established CpGODNs on the cellular responses of the fish immunocytes Incubation of the HK leukocytes with 2 μM concentration of the CpGODNs resulted in enhanced respiratory burst There were differential effects on the activities of acid phosphatase and cellular myeloperoxidase Only CpGODN 1826 triggered a significant increase in the level of both enzymes On the other hand the supernatants derived from the HK leukocytes after incubation with different CpGODNs did not possess bactericidal activity against Vibrio anguillarum and Aeromonas salmonicida This study has shown that CpGODNs at low concentrations are able to stimulate respiratory burst in cod but have minimal effects on cellular enzymatic activities and antibacterial action

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